Table 2 Rmax, pIC30 and pIC50 of propofol on rat pulmonary and aorta and on human pulmonary artery precontracted by KCl and PHE
From: Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary artery
Rmax (%control) | pIC30 (M) | pIC50 (M) | n | ||
|---|---|---|---|---|---|
normoxic rat PA | KCl | 94.0 ± 2.3*° | 4.69 ± 0.14*‡° | 4.35 ± 0.14‡° | 7 |
PHE | 46.1 ± 9.1† | 3.54 ± 0.26† | 1.96 ± 0.76† | 7 | |
human PA | KCl | 66.5 ± 11.8 | 3.69 ± 0.16‡ | 3.01 ± 0.30‡ | 7 |
PHE | 51.6 ± 15.0 | 3.33 ± 0.34 | 3.00 ± 0.49 | 7 | |
CH rat PA | KCl | 127.4 ± 15.9 | 4.83 ± 0.17 | 4.49 ± 0.17 | 9 |
PHE | 90.1 ± 11.7 | 4.30 ± 0.17 | 3.86 ± 0.23 | 6 | |
normoxic rat aorta | KCl | 79.9 ± 5.3* | 4.32 ± 0.10* | 3.89 ± 0.14* | 9 |
PHE | 48.1 ± 5.3† | 3.53 ± 0.14 | 2.69 ± 0.38 | 7 | |
CH rat aorta | KCl | 101.3 ± 16.7 | 4.45 ± 0.10 | 4.15 ± 0.11 | 8 |
PHE | 73.1 ± 5.0 | 4.09 ± 0.24 | 3.61 ± 0.20 | 6 |