Figure 6
From: Human physiologically based pharmacokinetic model for propofol
Individual PBPK model fits to the experimental data for the middle aged subjects. The values of the 3 parameters that provided the best fit for each individual subject are listed (see fig. 5). For 6 of the 8 subjects there was no pulmonary sequestration of the bolus dose. In order to fit the data for subject 2–4, a small amount of extra-hepatic metabolism was required (kidney clearance = Tclrkid = 35).