Table 2 NNT for at least 50% pain relief in dental pain
From: Individual patient meta-analysis of single-dose rofecoxib in postoperative pain
| Â | Â | Improved with | Â | Â | Mean percent improved with | ||
|---|---|---|---|---|---|---|---|
Number of trials | Drug and dose (mg) | Active | Placebo | Relative risk (95% CI) | NNT (95% CI) | Placebo | Active |
Six hours | |||||||
13 | Rofecoxib 50 mg | 832/1330 | 58/570 | 5.9 (4.6 to 7.5) | 1.9 (1.8 to 2.1) | 10 | 63 |
6 | Ibuprofen 400 mg | 159/303 | 25/298 | 6.3 (4.2 to 9.2) | 2.3 (2.0 to 2.7) | 9 | 53 |
1 | Diclofenac 50 mg | 32/121 | 8/63 | 2.1 (1.02 to 4.2) | 7.3 (4.0 to 42) | 13 | 26 |
2 | Naproxen 550 mg | 52/88 | 9/87 | 5.7 (3.0 to 11) | 2.1 (1.6 to 2.7) | 11 | 59 |
2 | Oxycodone 5 mg + paracetamol 325 mg | 30/180 | 5/61 | 2.0 (0.8 to 5.0) | nc | 8 | 17 |
2 | Paracetamol 600 mg + codeine 60 mg | 102/360 | 11/61 | 1.6 (0.9 to 2.7) | nc | 18 | 28 |
Eight hours | |||||||
13 | Rofecoxib 50 mg | 814/1330 | 62/570 | 5.4 (4.3 to 6.9) | 2.0 (1.9 to 2.1) | 11 | 61 |
6 | Ibuprofen 400 mg | 135/303 | 25/298 | 5.3 (3.6 to 7.9) | 2.8 (2.4 to 3.4) | 8 | 44 |
1 | Diclofenac 50 mg | 32/121 | 11/63 | 1.5 (0.8 to 2.8) | nc | 17 | 26 |
6 | Ibuprofen 400 mg | 135/303 | 25/298 | 5.3 (3.6 to 7.9) | 2.8 (2.4 to 3.4) | 8 | 44 |
2 | Naproxen 550 mg | 45/88 | 8/87 | 5.6 (2.8 to 11) | 2.4 (1.9 to 3.4) | 10 | 51 |
2 | Oxycodone 5 mg + paracetamol 325 mg | 21/180 | 4/61 | 1.8 (0.6 to 5.0) | nc | 6 | 12 |
2 | Paracetamol 600 mg + codeine 60 mg | 70/360 | 10/61 | 1.2 (0.7 to 2.1) | nc | 16 | 20 |
Twelve hours | |||||||
13 | Rofecoxib 50 mg | 662/1330 | 46/570 | 5.9 (4.5 to 7.8) | 2.4 (2.2 to 2.6) | 8 | 50 |
6 | Ibuprofen 400 mg | 73/303 | 19/298 | 3.8 (2.4 to 6.1) | 5.6 (4.3 to 8.2) | 6 | 24 |
1 | Diclofenac 50 mg | No data – doses repeated every 8 hours |  |  |  | ||
6 | Ibuprofen 400 mg | 73/303 | 19/298 | 3.8 (2.4 to 6.1) | 5.6 (4.3 to 8.2) | 6 | 24 |
2 | Naproxen 550 mg | 30/88 | 7/87 | 4.2 (2.0 to 9.1) | 3.9 (2.7 to 7.0) | 8 | 34 |
2 | Oxycodone 5 mg + paracetamol 325 mg | 15/180 | 2/61 | 2.5 (0.6 to 11) | nc | 3 | 8 |
2 | Paracetamol 600 mg + codeine 60 mg | 30/360 | 8/61 | 0.6 (0.3 to 1.3) | nc | 13 | 8 |
Twenty-four hours | |||||||
13 | Rofecoxib 50 mg | 595/1330 | 49/570 | 5.1 (3.9 to 6.7) | 2.8 (2.5 to 3.1) | 9 | 45 |
6 | Ibuprofen 400 mg | 43/303 | 21/298 | 2.0 (1.2 to 3.3) | 14 (8.3 to 44) | 7 | 14 |
1 | Diclofenac 50 mg | No data – doses repeated every 8 hours |  |  |  | ||
6 | Ibuprofen 400 mg | 43/303 | 21/298 | 2.0 (1.2 to 3.3) | 14 (8.3 to 44) | 7 | 14 |
2 | Naproxen 550 mg | 24/88 | 8/87 | 3.0 (1.4 to 6.2) | 5.5 (3.4 to 14) | 9 | 27 |
2 | Oxycodone 5 mg + paracetamol 325 mg | 18/1804 | 61 | 1.4 (0.5 to 3.6) | nc | 7 | 10 |
2 | Paracetamol 600 mg + codeine 60 mg | 24/360 | 7/61 | 0.6 (0.3 to 1.2) | nc | 11 | 7 |