From: Covariates of intravenous paracetamol pharmacokinetics in adults
Reference | ref 8 | ref 9 | ref 11 | ref 10 | ref 12 | ref 13 | ref 11 | ref 11 | Ref 11 |
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Characteristics | 12 healthy males | 12 healthy males | 8 healthy females | Orthopaedic surgery | High dependency and IC, 38 cases | Abdominal surgery | Caesarean delivery | Postpartum early | Postpartum late, |
14 healthy females | Â | 40 cases | 20 cases | 41 cases | 8 cases (15Â weeks) | 7 cases (1Â year) | |||
Study design | Single iv bolus, 0.5Â g | iv loading dose 2Â g, | single iv bolus, 2Â g | Single iv bolus, 1Â g | Single iv bolus, 1Â g | repeated 1Â g, 6 qh | iv loading dose 2Â g, maintenance 1Â g q6h | iv loading 2Â g | iv loading 2Â g |
Maintenance 1 g q6h | 48–72 h | ||||||||
Weight | 63-83Â kg | 49-94Â kg | 54-74Â kg | 58-107Â kg | 53-120Â kg | 57-101Â kg | 57-110Â kg | 52-88Â kg | 50-87Â kg |
Age | 21-25 years | 19-34 years | 27-37 years | 20-88 years | 34-82 years | 44-85 years | 31, SD 5.8Â years | 31, SD 5.8Â years | 32, SD 6Â years |
Sampling strategy | 13 samples/case | 32 samples/case | 4 samples/case | 20 samples/case | 8 samples/case | 2x9 samples/case | 4 samples after loading dose + up to 24 h | 4 samples/case | 4 samples/case, |
up to 24Â h | up to 48Â h | up to 6Â h | up to 24Â h | up to 6Â h | up to 72Â h | up to 6Â h | up to 6Â h | ||
Analytical technique | HPLC-uv | HPLC-uv | HPLC-uv | HPLC | Fluorescent polarization immuno-assay | HPLC | HPLC-uv | HPLC-uv | HPLC-uv |
LLOQ | < 0.1 μg/ml | < 0.02 μg/ml | < 0.08 μg/ml | < 0.25 μg/ml | < 0.2 μg/ml | n.a. | < 0.08 μg/ml | < 0.08 μg/ml | < 0.08 μg/ml |
CV% | <6.4% | < 3% | < 15% | < 12.8% | < 7.5% | n.a. | < 15% | < 15% | < 15% |