Table 2 Epidemiologic and clinical characteristics of the 224 included patients and their relationship to hospital mortality

IHD within 48 hours

9 (5.4)

5 (8.6)

0.386

CRRT within 48 hours

11 (6.6)

15 (25.9)

<0.01

Stress dose steroid

61 (36.8)

29 (50.0)

0.076

Gram stain of organisms isolated from all cultures

  Fungi or parasite

4 (2.4)

1 (1.7)

0.761

  Gram positive

48 (28.9)

26 (44.8)

0.027

  Gram negative

80 (48.2)

21 (36.2)

0.114

  Polymicrobial

34 (20.5)

10 (17.2)

0.593

Concomitant positive culture (when culture results available)

  Respiratory

17 (13.4)

8 (18.6)

0.404

  Urine

53 (34.4)

10 (20.4)

0.065

Primary bacteremia

16 (9.6)

9 (15.5)

0.221

Source of infection if secondary bacteremia^a,b

  Skin soft tissue

20 (12.1)

6 (10.3)

0.727

  Respiratory

30 (18.1)

11 (19.0)

0.880

  Urinary

57 (34.3)

9 (15.5)

0.007

  Intra-abdominal

20 (12.1)

16 (27.6)

0.006

  Unknown

22 (13.3)

5 (8.6)

0.351

Source control procedure if intra-abdominal source^c

16 (80.0)

13 (81.3)

0.925

Median time to source control, hours (IQR)^c

13.5 (0.7-65.0)

13.9 (4.9-51.4)

0.568

Vasopressor for at least 1 hour

96 (57.8)

43 (74.1)

0.028

Antimicrobials administered^d,e

  Carbapenem (not ertapenem)

48 (28.9)

11 (19.0)

0.139

  Cefepime

33 (19.9)

17 (29.3)

0.138

  Ceftriaxone

20 (12.1)

10 (17.2)

0.318

  Clindamycin

9 (5.4)

4 (6.9)

0.679

  Fluoroquinolone

130 (78.3)

43 (74.4)

0.514

   Levofloxacin

103 (62.1)

32 (55.2)

0.357

  Metronidazole

12 (7.2)

11 (19.0)

0.011

  Piperacillin/tazobactam

89 (53.6)

28 (48.3)

0.484

  Vancomycin

142 (85.5)

47 (81.0)

0.416

  Antifungal agent

4 (2.4)

2 (3.5)

0.673

Appropriate antimicrobial therapy administered <1 hr

128 (77.1)

41 (70.7)

0.328

Time to appropriate antimicrobial therapy, hours, median (IQR)

0 (0-0.87)

0.23 (0-1.08)

0.033