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Table 2 Sequential changes in variables of lung mechanics and hemodynamics

From: Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS

Variables

Group

Baseline

Injury

1 Hr

2 Hr

3 Hr

4 Hr

5 Hr

6 Hr

PIP, cmH2O

OS

13.0 ± 3.0

19.3 ± 3.0a

22.6 ± 2.1ad

23.0 ± 2.6

23.0 ± 2.1

23.8 ± 2.1

24.6 ± 2.6 b

24.9 ± 2.9 b

 

CS

13.2 ± 1.7

19.4 ± 2.6a

21.2 ± 1.6 d

21.3 ± 2.3

21.3 ± 2.3

21.5 ± 1.9 c

21.5 ± 2.2 c

21.8 ± 2.2 c

 

Control

13.2 ± 2.0

20.5 ± 2.1a

20.8 ± 1.0d

21.3 ± 1.0

21.0 ± 1.3

20.3 ± 1.4 c

19.8 ± 1.2c

19.2 ± 1.5 c

 

HC

13.7 ± 1.5

17.7 ± 0.6

17.3 ± 0.6

19.3 ± 1.2

19.6 ± 2.3

19.3 ± 2.5 c

19.0 ± 2.0 c

18.3 ± 1.2 c

Arterial pH

OS

7.43 ± 0.03

7.05 ± 0.14a

7.15 ± 0.13a

7.14 ± 0.13

7.11 ± 0.12

7.09 ± 0.15

7.09 ± 0.17

7.11 ± 0.14

 

CS

7.40 ± 0.05

7.11 ± 0.15a

7.16 ± 0.11

7.15 ± 0.10

7.16 ± 0.14

7.12 ± 0.14

7.14 ± 0.08

7.17 ± 0.09

 

Control

7.48 ± 0.08

7.20 ± 0.08a

7.22 ± 0.06

7.23 ± 0.06

7.26 ± 0.03

7.26 ± 0.05

7.24 ± 0.05

7.22 ± 0.06

 

HC

7.41 ± 0.06

7.22 ± 0.04

7.24 ± 0.02

7.23 ± 0.03

7.22 ± 0.03

7.24 ± 0.05

7.24 ± 0.05

7.20 ± 0.04

MAP, mmHg

OS

131 ± 17

118 ± 20

98 ± 14a

102 ± 16

101 ± 14b

100 ± 20

97 ± 11

95 ± 16

 

CS

119 ± 13

121 ± 18

101 ± 14a

102 ± 12

94 ± 15

94 ± 16

94 ± 16

91 ± 15

 

Control

116 ± 7

119 ± 11

93 ± 10 a

95 ± 11

96 ± 9

102 ± 13

106 ± 13

105 ± 9

 

HC

118 ± 2

111 ± 6

105 ± 13

112 ± 26

100 ± 15

96 ± 6

102 ± 16

105 ± 15

HR, beats/min

OS

241 ± 64

209 ± 31

217 ± 43

215 ± 24

200 ± 19

211 ± 36

211 ± 37

207 ± 31

 

CS

214 ± 49

195 ± 29

221 ± 49

218 ± 32

227 ± 43

224 ±49

208 ± 34

212 ± 27

 

Control

272 ± 49

242 ± 53

244 ± 30

253 ± 37

252 ± 37c

243 ± 39

232 ± 39

235 ± 20

 

HC

299 ± 38

207 ± 140

231 ± 11

228 ± 24

225 ± 11

253 ± 15

247 ± 45

235 ± 44

  1. OS, open endotracheal suctioning; CS, closed endotracheal suctioning; HC, Healthy control; PIP, peak inspiratory pressure; MAP, mean arterial pressure; HR, heart rate. a p < 0.05 compared with previous value within the same group; b p < 0.05 compared with 1 hour after injury within the same group; c p < 0.05 vs. OS group; d p < 0.05 vs. HC group. Values are mean ± SD.