Table 2 Baseline characteristics
Characteristica | Intravenous colistin only (n = 51) | Intravenous + aerosolized colistin (n = 44) | p- value |
|---|---|---|---|
Age (years) | 57.3 ± 15.6 | 60.9 ± 15.3 | 0.255 |
Male | 33 (64.7) | 22 (50) | 0.148 |
ICU | 0.279 | ||
Medical | 30 (58.8) | 21 (47.7) | |
Surgical | 21 (41.2) | 23 (52.3) | |
Co-morbidities | |||
Hypertension | 30 (58.8) | 33 (75.0) | 0.096 |
Diabetes | 17 (33.3) | 19 (43.2) | 0.324 |
CKD | 10 (19.6) | 7 (15.9) | 0.639 |
ESRD | 6 (11.8) | 2 (4.5) | 0.279 |
Solid organ transplant | 3 (5.9) | 0 | 0.246 |
BMT | 1 (2.0) | 1 (2.3) | >0.99 |
Hematologic malignancy | 5 (9.8) | 4 (9.1) | >0.99 |
Solid malignancy | 12 (23.5) | 5 (11.4) | 0.123 |
Chronic immunosuppressive therapy | 21 (41.2) | 13 (29.5) | 0.238 |
Microbiologic history | |||
Acinetobacter spp. | 5 (9.8) | 5 (11.4) | >0.99 |
Pseudomonas spp. | 21 (41.2) | 12 (27.3) | 0.156 |
VRE | 15 (29.4) | 12 (27.3) | >0.99 |
MRSA | 19 (37.3) | 18 (40.9) | 0.716 |
ESBL | 10 (19.6) | 1 (2.3) | 0.008 |
Hospital admission within last 90 days | 25 (49.0) | 23 (52.3) | 0.752 |
Broad spectrum antibiotics within last 90 days | 33 (64.7) | 23 (52.3) | 0.219 |
Transfer from long-term care facility | 18 (35.3) | 14 (31.8) | 0.721 |
Transfer from outside hospital | 16 (31.4) | 10 (22.7) | 0.346 |
APACHE II score | 24 ± 6.9 | 22.4 ± 7.1 | 0.266 |
Serum creatinine at colistin initiation (mg/dl) | 1.3 ± 1.1 | 1.4 ± 0.9 | 0.808 |
Mechanical ventilation | 49 (96.1) | 42 (95.5) | >0.999 |