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Table 3 Summated fluid loading steps, with responsiveness defined as ≥10% and ≥15% increase in cardiac index (CI), when systolic cardiac function is reduced or near-normal at 20% cutoff of global ejection fraction (GEF)

From: Global end-diastolic volume increases to maintain fluid responsiveness in sepsis-induced systolic dysfunction

 

GEF <20% (n = 9)

GEF ≥20% (n = 7)

CI ≥10%

R

NR

P-value

R

NR

P-value

 

(n = 9 steps in 6 patients)

(n = 18 steps in 9 patients)

 

(n = 6 stepsin 5 patients)

(n = 15 steps in 7 patients)

 

CI, L/min/m2

baseline

3.7 ± 0.7

3.5 ± 0.7

0.04

3.6 ± 1.2

5.0 ± 1.5

0.008

after

4.4 ± 0.8

3.4 ± 0.6

 

4.3 ± 1.4

5.0 ± 1.5

 

change

0.7 ± 0.3

0 ± 0.3

n.a.

0.7 ± 0.3

0 ± 0.2

n.a.

CVP, mm Hg

      

baseline

9 ± 6

11 ± 5

0.41

10 ± 3

10 ± 3

0.68

after

10 ± 6

12 ± 4

10 ± 2

11 ± 3

  

change

1 ± 1

1 ± 2

<0.001

1 ± 2

2 ± 1

0.004

GEDVI, mL/m2

baseline

1007 ± 306

870 ± 236

0.002

801 ± 186

834 ± 163

0.83

after

1102 ± 313

858 ± 208

872 ± 199

843 ± 167

  

change

96 ± 59

−12 ± 54

<0.001

70 ± 85

8 ± 38

<0.001

PBVI, mL/m2

baseline

215 ± 95

203 ± 64

0.25

212 ± 51

225 ± 50

0.86

after

250 ± 54

204 ± 52

224 ± 40

227 ± 50

  

change

34 ± 63

1 ± 69

<0.001

11 ± 52

2 ± 53

<0.001

Fluid, mL

522 ± 120

467 ± 161

0.07

450 ± 176

467 ± 145

0.75

Gelatin/HES/

3/1/5

6/5/7

0.65

5/6/4

1/3/2

0.24

albumin

CI ≥15%

R

NR

P-value

R

NR

P-value

 

(n = 4 steps in 4 patients)

(n = 23 steps in 9 patients)

 

(n = 5 steps in 4 patients)

(n = 16 steps in 7 patients)

 

CI, L/min/m2

baseline

3.6 ± 1.0

3.6 ± 0.7

0.50

3.6 ± 1.3

4.9 ± 1.5

0.01

after

4.4 ± 1.1

3.7 ± 0

4.4 ± 1.5

5.0 ± 1.5

  

change

0.9 ± 0.3

0.1 ± 0.3

na

0.8 ± 0.3

0 ± 0.2

na

CVP, mm Hg

baseline

10 ± 4

11 ± 5

0.59

9 ± 3

10 ± 3

0.61

after

11 ± 4

12 ± 5

10 ± 3

11 ± 3

  

change

1 ± 1

1 ± 1

0.76

1 ± 2

1 ± 1

0.05

GEDVI, mL/m2

baseline

802 ± 214

935 ± 271

0.26

814 ± 205

829 ± 160

0.83

after

935 ± 254

940 ± 277

886 ± 219

841 ± 162

  

change

133 ± 42

5 ± 63

<0.001

73 ± 96

12 ± 39

<0.001

PBVI, mL/m2

baseline

159 ± 105

216 ± 67

0.17

213 ± 57

224 ± 48

0.68

after

218 ± 26

220 ± 60

215 ± 38

230 ± 50

  

change

59 ± 87

4 ± 63

0.56

1 ± 51

6 ± 53

<0.001

Fluid, mL

600 ± 0

465 ± 153

<0.001

460 ± 195

462 ± 140

0.84

Gelatin/HES/

1/1/2

8/5/10

0.67

1/3/1

5/6/5

1.0

albumin

  1. Mean ± SD or number of patients where appropriate. Abbreviations: R, Responders, NR Non-responders, CI Cardiac index, GEF Global ejection fraction, R Responding fluid loading step, NR non-responding fluid loading step, CVP Central venous pressure, GEDVI Global end-diastolic volume index, PBVI Pulmonary blood volume index, HES Hydroxyethyl starch, n.a. not applicable.
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BMC Anesthesiology

ISSN: 1471-2253

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