Table 2 Patient characteristics

(n = 9)

(n = 7)

P value

Age

62 ± 9

57 ± 9

0.32

Male/female

7/2

4/3

0.60

APACHE II

16 ± 4

12 ± 5

0.08

Cardiac premorbidity

4

1

0.31

Sepsis origin

0.38

pulmonary

4

3

abdominal

2

0

CNS

0

1

urogenital

1

0

unknown

2

3

Bloodstream infection

0.41

Gram-

2

Gram+

2

2

Fungi

1

PEEP, cm H₂O

14 ± 6

12 ± 3

0.17

Tidal volume, mL/kg

8.0 ± 0.8

9.0 ± 1.6

0.08

P_aO₂/F_IO₂

209 ± 54

193 ± 62

0.60

Lung injury score

2.2 ± 0.8

2.5 ± 0.8

0.60

ICU mortality

4

2

0.37

Haemodynamics

HR, /min

t = 0

106 ± 18

90 ± 25

0.15

t = 90

103 ± 16

95 ± 22

0.42

MAP, mm Hg

t = 0

73 ± 12

74 ± 9

0.84

t = 90

88 ± 19¹

89 ± 13¹

0.87

CVP, mm Hg

t = 0

9 ± 5

8 ± 3

0.61

t = 90

12 ± 5²

12 ± 3²

0.83

CI, L/min

t = 0

3.3 ± 0.6

4.3 ± 1.5

0.06

t = 90

3.9 ± 1.0²

5.0 ± 1.4³

0.09

SVI, mL/m²

t = 0

31 ± 6

49 ± 12

0.002

t = 90

38 ± 9¹

53 ± 11

0.01

LVSWI, gm/m²

t = 0

27 ± 5

43 ± 8

<0.001

t = 90

39 ± 11³

55 ± 11⁴

0.01

GEDVI, mL/m²

t = 0

891 ± 257

787 ± 140

0.35

t = 90

963 ± 273¹

866 ± 170¹

0.43

GEF,%

t = 0

15 ± 2

25 ± 5

n.a.

t = 90

16 ± 4

25 ± 7

0.005

CFI, 1/min

t = 0

15.2 ± 2.9

22.1 ± 6.2

0.01

t = 90

16.8 ± 4.0

23.4 ± 5.5

0.01

LVSWI/GEDVI, gm/mL

t = 0

0.13 ± 0.04

0.22 ± 0.04

<0.001

t = 90

0.17 ± 0.07^{4, 3}

0.26 ± 0.07

0.02

Norepinephrine and/or dopamine

8

6

0.70

Norepinephrine, μg/kg/min

0.09 ± 0.11

0.06 ± 0.12

0.25

Dopamine, μg/kg/min

5.6 ± 3.4

4.9 ± 4.3

0.92

Fluid, mL

1456 ± 296

1271 ± 269

0.22

Gelatin/HES/albumin

3/2/4

2/3/2

0.66