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Section edited by Jun Lin
This section considers studies on the pharmacology and pharmacokinetics of anesthetic and analgesic compounds, as well as other more laboratory focused and experimental studies.
Research article
Ketamine is a frequently used intravenous anesthetic, which can reversibly induce loss of consciousness (LOC). Previous studies have demonstrated that thalamocortical system is critical for information transmi...
BMC Anesthesiology 2017 17:111
Published on: 23 August 2017
Research article
Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether...
BMC Anesthesiology 2017 17:73
Published on: 30 May 2017
Research article
Mivacurium is the shortest acting nondepolarizing muscle relaxant currently available; however, the effect of different dosages and injection times of intravenous mivacurium administration in children of diffe...
BMC Anesthesiology 2017 17:58
Published on: 17 April 2017
Research article
A moderate insufflation pressure and deep neuromuscular blockade (NMB) have been recommended in laparoscopic surgery in consideration of the possible reduction in splanchnic perfusion due to the CO2-pneumoperiton...
BMC Anesthesiology 2017 17:45
Published on: 20 March 2017
Research article
Perioperative cerebral ischemia/hypoxia could induce hippocampal injury and has been reported to induce cognitive impairment. In this study, we used cobalt chloride (CoCl2) to build a hypoxia model in mouse hippo...
BMC Anesthesiology 2017 17:32
Published on: 28 February 2017
Research article
Remifentanil induced hyperalgesia (RIH) is characterized by stimulation evoked pain including allodynia and thermal hyperalgesia after remifentanil infusion. N-methyl-D-aspartate (NMDA) receptor was reported t...
BMC Anesthesiology 2017 17:30
Published on: 21 February 2017
Research article
Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-indu...
BMC Anesthesiology 2017 17:18
Published on: 2 February 2017
Research article
Remifentanil has been reported to cause post-anesthetic shivering (PAS). Higher doses of remifentanil reportedly induce more intense PAS. Tramadol, a synthetic opioid that acts at multiple sites, is considered...
BMC Anesthesiology 2017 17:1
Published on: 3 January 2017
Research article
Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of ancillary properties. Our aim was to investigate lidocaine’s vasoreactivity properties in intact versus denuded rat thorac...
BMC Anesthesiology 2016 16:121
Published on: 3 December 2016
Research article
The local anesthetic lidocaine can affect intra- and extra-cellular signaling pathways in both neuronal and non-neuronal cells, resulting in long-term modulation of biological functions, including cell growth ...
BMC Anesthesiology 2016 16:104
Published on: 24 October 2016
Research article
It has been observed that patients with liver dysfunction need lower dose anesthetic compared patients with normal liver function. The minimum amount of volatile anesthetic to achieve an optimal depth of anest...
BMC Anesthesiology 2016 16:98
Published on: 18 October 2016
Research article
Propofol is a widely used intravenous anesthetic that is well-known for its protective effect in various human and animal disease models. However, the effects of propofol on neurogenesis, especially on the dev...
BMC Anesthesiology 2016 16:95
Published on: 13 October 2016
Research article
Clonidine effectively decreases perioperative mortality by reducing sympathetic tone. However, application of clonidine might also restrict anaemia tolerance due to impairment of compensatory mechanisms. There...
BMC Anesthesiology 2016 16:93
Published on: 12 October 2016
Research article
Activation of NMDA receptors play an important role in the development of remifentanil-induced hyperalgesia. We hypothesized that in addition to ketamine, intrathecal MgSO4 could also relieve thermal and mechanic...
BMC Anesthesiology 2016 16:74
Published on: 6 September 2016
Research article
We conducted a prospective, randomized, multicenter study to evaluate the differences in the blocking effect of different doses of rocuronium between sevoflurane- or propofol-remifentanil anesthesia in an Asia...
BMC Anesthesiology 2016 16:65
Published on: 22 August 2016
Research article
Class II phosphoinositide 3-kinase α-isoform (PI3K-C2α) is involved in regulating KCl-induced vascular smooth muscle contraction. The current study was to investigate the effects of sevoflurane (SEVO) and isof...
BMC Anesthesiology 2016 16:63
Published on: 18 August 2016
Research article
Ramosetron is a relatively new 5-hydroxytryptamine three receptor antagonist with higher binding affinity and more prolonged duration of action compared to ondansetron. The present study was performed to evalu...
BMC Anesthesiology 2016 16:56
Published on: 3 August 2016
Research article
Blood salvage systems help to minimize intraoperative transfusion of allogenic blood. So far no data is available on the use of argatroban for anticoagulation of such systems.
BMC Anesthesiology 2016 16:37
Published on: 15 July 2016
Research article
Ketamine is a commonly used clinical anesthetic and a popular recreational drug. However, with the exception of studies about the nervous system, studies about the effect of early ketamine exposure on embryos ...
BMC Anesthesiology 2016 16:23
Published on: 18 April 2016
Research article
Temozolomide (TMZ) induces a G2/M cell cycle arrest and is used for treatment of paediatric tumours, especially neuroblastomas. Patients treated with TMZ frequently receive midazolam for sedation prior to surg...
BMC Anesthesiology 2015 15:151
Published on: 17 October 2015
