General pharmacology and pharmacokinetics

Section edited by Jun Lin

This section considers studies on the pharmacology and pharmacokinetics of anesthetic and analgesic compounds, as well as other more laboratory focused and experimental studies.

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  1. Research article

    Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral oxygenation during shoulder surgery in the beach chair position: a prospective, single-blind study

    Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether...

    Eun-A Jang, Ji-A Song, Ji Youn Shin, Jae Joon Yoon, Kyung Yeon Yoo and Seongtae Jeong

    BMC Anesthesiology 2017 17:73

    Published on: 30 May 2017

  2. Research article

    The efficacy and safety of mivacurium in pediatric patients

    Mivacurium is the shortest acting nondepolarizing muscle relaxant currently available; however, the effect of different dosages and injection times of intravenous mivacurium administration in children of diffe...

    Ruifeng Zeng, Xiulan Liu, Jing Zhang, Ning Yin, Jian Fei, Shan Zhong, Zhiyong Hu, Miaofeng Hu, Mazhong Zhang, Bo Li, Jun Li, Qingquan Lian and Wangning ShangGuan

    BMC Anesthesiology 2017 17:58

    Published on: 17 April 2017

  3. Research article

    Changes in duration of action of rocuronium following decrease in hepatic blood flow during pneumoperitoneum for laparoscopic gynaecological surgery

    A moderate insufflation pressure and deep neuromuscular blockade (NMB) have been recommended in laparoscopic surgery in consideration of the possible reduction in splanchnic perfusion due to the CO2-pneumoperiton...

    Yang Liu, Wen Cao, Yu Liu, Yun Wang, Ren Lang, Yun Yue and An-Shi Wu

    BMC Anesthesiology 2017 17:45

    Published on: 20 March 2017

  4. Research article

    The protective effects of propofol against CoCl2-induced HT22 cell hypoxia injury via PP2A/CAMKIIα/nNOS pathway

    Perioperative cerebral ischemia/hypoxia could induce hippocampal injury and has been reported to induce cognitive impairment. In this study, we used cobalt chloride (CoCl2) to build a hypoxia model in mouse hippo...

    Yan Lu, Wei Chen, Chen Lin, Jiaqiang Wang, Minmin Zhu, Jiawei Chen and Changhong Miao

    BMC Anesthesiology 2017 17:32

    Published on: 28 February 2017

  5. Research article

    Magnesium sulphate attenuate remifentanil-induced postoperative hyperalgesia via regulating tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord

    Remifentanil induced hyperalgesia (RIH) is characterized by stimulation evoked pain including allodynia and thermal hyperalgesia after remifentanil infusion. N-methyl-D-aspartate (NMDA) receptor was reported t...

    Jiehao Sun, Hai Lin, Guodong He, Wendong Lin and Jianping Yang

    BMC Anesthesiology 2017 17:30

    Published on: 21 February 2017

  6. Research article

    Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest

    Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-indu...

    Bingjing Wu, Yong G. Peng, Shishi Zhao, Nana Bao, Linmin Pan, Jiaojiao Dong, Xuzhong Xu and Quanguang Wang

    BMC Anesthesiology 2017 17:18

    Published on: 2 February 2017

  7. Research article

    The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

    The local anesthetic lidocaine can affect intra- and extra-cellular signaling pathways in both neuronal and non-neuronal cells, resulting in long-term modulation of biological functions, including cell growth ...

    Akihisa Okamoto, Masahiro Tanaka, Chisato Sumi, Kanako Oku, Munenori Kusunoki, Kenichiro Nishi, Yoshiyuki Matsuo, Keizo Takenaga, Koh Shingu and Kiichi Hirota

    BMC Anesthesiology 2016 16:104

    Published on: 24 October 2016

  8. Research article

    Effect of the severity of liver dysfunction on the minimum alveolar concentration of sevoflurane responding to an electronic stimulation in cirrhotic patients

    It has been observed that patients with liver dysfunction need lower dose anesthetic compared patients with normal liver function. The minimum amount of volatile anesthetic to achieve an optimal depth of anest...

    Yan Yin, Hong Xiao, Jirimutuya Han, Weiyi Zhang, Jianguo Cheng and Tao Zhu

    BMC Anesthesiology 2016 16:98

    Published on: 18 October 2016

  9. Research article

    Influence of clonidine induced sympathicolysis on anaemia tolerance in anaesthetized pigs

    Clonidine effectively decreases perioperative mortality by reducing sympathetic tone. However, application of clonidine might also restrict anaemia tolerance due to impairment of compensatory mechanisms. There...

    Patrick Lauscher, Harry Kertscho, Malte Krömker, Barbara Haberichter, Kai Zacharowski, Peter Rosenberger and Jens Meier

    BMC Anesthesiology 2016 16:93

    Published on: 12 October 2016

  10. Research article

    The neuromuscular effects of rocuronium under sevoflurane-remifentanil or propofol-remifentanil anesthesia: a randomized clinical comparative study in an Asian population

    We conducted a prospective, randomized, multicenter study to evaluate the differences in the blocking effect of different doses of rocuronium between sevoflurane- or propofol-remifentanil anesthesia in an Asia...

    Sangseok Lee, Young Jin Ro, Won Uk Koh, Tomoki Nishiyama and Hong-seuk Yang

    BMC Anesthesiology 2016 16:65

    Published on: 22 August 2016

  11. Research article

    Effect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgery

    Ramosetron is a relatively new 5-hydroxytryptamine three receptor antagonist with higher binding affinity and more prolonged duration of action compared to ondansetron. The present study was performed to evalu...

    Tae Kyong Kim, Youn Joung Cho, Chae-won Lim, Jeong Jin Min, Eue-Keun Choi, Deok Man Hong and Yunseok Jeon

    BMC Anesthesiology 2016 16:56

    Published on: 3 August 2016

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