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BMC Anesthesiology

General pharmacology and pharmacokinetics

Section edited by Jun Lin

This section considers studies on the pharmacology and pharmacokinetics of anesthetic and analgesic compounds, as well as other more laboratory focused and experimental studies.

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  1. Content type: Research article

    Previous studies have shown that cyclooxygenase-2, a key enzyme that converts arachidonic acid to prostaglandins, is involved in anxiety and cognitive processes, but few studies have investigated the effects o...

    Authors: Bo Wang, Xin Jin, Xin Kuang and Shaowen Tian

    Citation: BMC Anesthesiology 2017 17:152

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  2. Content type: Research article

    Studies have found that propofol can inhibit endotoxin-induced monocyte-macrophages to produce various inflammatory factors. This study is to disclose whether the propofol affects the expression of high-mobili...

    Authors: Jie Jia, Yijuan Sun, Zurong Hu, Yi Li and Xiangcai Ruan

    Citation: BMC Anesthesiology 2017 17:148

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  3. Content type: Research article

    The effectiveness of a combination of a lipid emulsion with epinephrine in reversing local anesthetic-induced cardiac arrest has been confirmed. The combination of a lipid emulsion with levosimendan, was shown...

    Authors: Fubei Nan, Xixi Cai, Yingchao Ye, Xuzhong Xu, Zhengqian Li, Min Li and Limei Chen

    Citation: BMC Anesthesiology 2017 17:128

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  4. Content type: Research article

    Isoflurane-induced neuroapoptosis and cognitive impairment has been previously reported. Hydrogen sulfide (H2S) has been shown to be a neuromodulator that is thought to have anti-apoptotic, anti-inflammatory, and...

    Authors: Xueyuan Hu, Li Luan, Wei Guan, Shuai Zhang, Bei Li, Wei Ji and Honggang Fan

    Citation: BMC Anesthesiology 2017 17:123

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  5. Content type: Research article

    There are growing concerns that anaesthetic exposure can cause extensive apoptotic degeneration of neurons and the impairment of normal synaptic development and remodelling. However, little attention has been ...

    Authors: Haiyun Guo, Zhengwu Peng, Liu Yang, Xue Liu, Yaning Xie, Yanhui Cai, Lize Xiong and Yi Zeng

    Citation: BMC Anesthesiology 2017 17:124

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  6. Content type: Research article

    Ketamine is a frequently used intravenous anesthetic, which can reversibly induce loss of consciousness (LOC). Previous studies have demonstrated that thalamocortical system is critical for information transmi...

    Authors: Bao Fu, Chengxi Liu, Yajun Zhang, Xiaoyun Fu, Lin Zhang and Tian Yu

    Citation: BMC Anesthesiology 2017 17:111

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  7. Content type: Research article

    Administration of arginine vasopressin (AVP) is associated with reducing jugular venous (SjvO2) and regional cerebral (rScO2) oxygen saturation under propofol-remifentanil (P/R) anaesthesia. We determined whether...

    Authors: Eun-A Jang, Ji-A Song, Ji Youn Shin, Jae Joon Yoon, Kyung Yeon Yoo and Seongtae Jeong

    Citation: BMC Anesthesiology 2017 17:73

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  8. Content type: Research article

    Mivacurium is the shortest acting nondepolarizing muscle relaxant currently available; however, the effect of different dosages and injection times of intravenous mivacurium administration in children of diffe...

    Authors: Ruifeng Zeng, Xiulan Liu, Jing Zhang, Ning Yin, Jian Fei, Shan Zhong, Zhiyong Hu, Miaofeng Hu, Mazhong Zhang, Bo Li, Jun Li, Qingquan Lian and Wangning ShangGuan

    Citation: BMC Anesthesiology 2017 17:58

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  9. Content type: Research article

    A moderate insufflation pressure and deep neuromuscular blockade (NMB) have been recommended in laparoscopic surgery in consideration of the possible reduction in splanchnic perfusion due to the CO2-pneumoperiton...

    Authors: Yang Liu, Wen Cao, Yu Liu, Yun Wang, Ren Lang, Yun Yue and An-Shi Wu

    Citation: BMC Anesthesiology 2017 17:45

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  10. Content type: Research article

    Perioperative cerebral ischemia/hypoxia could induce hippocampal injury and has been reported to induce cognitive impairment. In this study, we used cobalt chloride (CoCl2) to build a hypoxia model in mouse hippo...

    Authors: Yan Lu, Wei Chen, Chen Lin, Jiaqiang Wang, Minmin Zhu, Jiawei Chen and Changhong Miao

    Citation: BMC Anesthesiology 2017 17:32

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  11. Content type: Research article

    Remifentanil induced hyperalgesia (RIH) is characterized by stimulation evoked pain including allodynia and thermal hyperalgesia after remifentanil infusion. N-methyl-D-aspartate (NMDA) receptor was reported t...

    Authors: Jiehao Sun, Hai Lin, Guodong He, Wendong Lin and Jianping Yang

    Citation: BMC Anesthesiology 2017 17:30

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  12. Content type: Research article

    Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-indu...

    Authors: Bingjing Wu, Yong G. Peng, Shishi Zhao, Nana Bao, Linmin Pan, Jiaojiao Dong, Xuzhong Xu and Quanguang Wang

    Citation: BMC Anesthesiology 2017 17:18

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  13. Content type: Research article

    Remifentanil has been reported to cause post-anesthetic shivering (PAS). Higher doses of remifentanil reportedly induce more intense PAS. Tramadol, a synthetic opioid that acts at multiple sites, is considered...

    Authors: Taku Nakagawa, Miki Hashimoto, Yasunori Hashimoto, Kazuhiro Shirozu and Sumio Hoka

    Citation: BMC Anesthesiology 2017 17:1

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  14. Content type: Research article

    Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of ancillary properties. Our aim was to investigate lidocaine’s vasoreactivity properties in intact versus denuded rat thorac...

    Authors: Aryadi Arsyad and Geoffrey P. Dobson

    Citation: BMC Anesthesiology 2016 16:121

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  15. Content type: Research article

    The local anesthetic lidocaine can affect intra- and extra-cellular signaling pathways in both neuronal and non-neuronal cells, resulting in long-term modulation of biological functions, including cell growth ...

    Authors: Akihisa Okamoto, Masahiro Tanaka, Chisato Sumi, Kanako Oku, Munenori Kusunoki, Kenichiro Nishi, Yoshiyuki Matsuo, Keizo Takenaga, Koh Shingu and Kiichi Hirota

    Citation: BMC Anesthesiology 2016 16:104

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  16. Content type: Research article

    It has been observed that patients with liver dysfunction need lower dose anesthetic compared patients with normal liver function. The minimum amount of volatile anesthetic to achieve an optimal depth of anest...

    Authors: Yan Yin, Hong Xiao, Jirimutuya Han, Weiyi Zhang, Jianguo Cheng and Tao Zhu

    Citation: BMC Anesthesiology 2016 16:98

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  17. Content type: Research article

    Clonidine effectively decreases perioperative mortality by reducing sympathetic tone. However, application of clonidine might also restrict anaemia tolerance due to impairment of compensatory mechanisms. There...

    Authors: Patrick Lauscher, Harry Kertscho, Malte Krömker, Barbara Haberichter, Kai Zacharowski, Peter Rosenberger and Jens Meier

    Citation: BMC Anesthesiology 2016 16:93

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