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Table 4 Comparison of intraoperative hemodynamics and anesthesia depth

From: Study on the effectiveness and safety of ciprofol in anesthesia in gynecological day surgery: a randomized double-blind controlled study

 

T1

T2

T3

T4

T5

T6

T7

T8

T9

Ciprofol group

SBP, mmHg,mean ± SDs

129.0 ± 14.6

93.7 ± 14.0*

107.2 ± 17.1*

110.8 ± 14.9*

109.9 ± 11.3*

113.7 ± 14.3*

116.8 ± 23.5*

107.6 ± 14.1*

117.2 ± 11.9*

HR, beats/min,mean ± SDs

81.4 ± 15.1

66.1 ± 11.7*

68.5 ± 12.5*

64.2 ± 9.8*

60.9 ± 9.5*

61.8 ± 9.9*

57.3 ± 6.7*

61.7 ± 10.2*

69.3 ± 9.8*

BIS, mean ± SDs

96.2 ± 1.8

53.3 ± 10.2*

61.8 ± 10.7*

62.6 ± 10.1*

59.9 ± 9.5*

53.1 ± 8.6*

47.4 ± 10.0*

56.7 ± 10.3*

78.5 ± 7.9*

Propofol group

SBP, mmHg,mean ± SDs

132.2 ± 17.8

91.9 ± 11.2*

97.3 ± 15.9*

102.0 ± 14.5*

106.4 ± 14.0*

107.9 ± 15.6*

109.3 ± 16.8*

104.2 ± 15.7*

116.8 ± 14.6*

HR, beats/min,mean ± SDs

77.2 ± 11.8

63.6 ± 8.6*

64.8 ± 8.8*

62.4 ± 7.8*

60.9 ± 6.4*

58.0 ± 6.2*

57.9 ± 7.7*

60.5 ± 7.5*

68.6 ± 9.6*

BIS, mean ± SDs

95.8 ± 2.2

56.0 ± 11.9*

64.8 ± 10.1*

66.9 ± 7.6*

62.5 ± 7.5*

63.8 ± 9.1*

62.5 ± 9.4*

64.1 ± 7.8*

81.6 ± 5.6*

P-value

SBP

0.269

0.423

0.001

0.001

0.119

0.166

0.381

0.198

0.848

HR

0.078

0.166

0.057

0.165

0.983

0.096

0.833

0.426

0.689

BIS

0.271

0.169

0.108

0.008

0.135

0.000

0.001

0.000

0.010

  1. Note: T 1: Before Anesthesia, T 2: before endotracheal intubation, T 3:1 min after endotracheal intubation, T 4: at the beginning of surgery, T 5:5 min after surgery, T 6:10 min after surgery, T 7:15 min after surgery, T 8: At the end of Surgery, T 9: after extubation.Comparison with T1, *P < 0. 05