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Table 1 Summary of the details of the included studies

From: Application of cardiovascular interventions to decrease blood loss during hepatectomy: a systematic review and meta-analysis

Study

Country

Sample size

Men/Women

Average age

Indication

NO. of cirrhotics

Type of surgery

NO. of major hepatectomies

Intervention

Comparison

Chen H (1997) [27]

USA

I:7 C:9

7/9

57.8 years

MCC

1

Major hepatic resection

16

ANH

Control

Eid E (2005) [28]

Eygpt

I:15 C:15

15/15

Not stated

Not stated

Not stated

Consecutive hepatectomy

Not stated

Limiting infusion volume, nitroglycerine, fentanyl to low CVP

Routine fluid management

El-kharboutly (2004) [29]

Eygpt

I:20 C:20

23/17

51.1 years

Not stated

40

Elective liver resection

25

Low CVP using nitroglycerine infusion

Control

Guo JR (2010) [30]

China

I:15 C:15

22/8

65 years

Not stated

Not stated

Hepatic carcinectomy

Not stated

Acute normovolemic dilution

No intervention

Guo JR (2015) [16]

China

I:40 C:20

38/22

50 years

Not stated

Not stated

Liver resection

Not stated

1. Low CVP

2. Low CVP + Acute normovolemic dilution

Control

Hashimoto (2007) [31]

Japan

I:40 C:39

49/30

33.5 years

Liver donor

0

Liver graft procurement

77

Autologous blood donation

Control

Jarnagin WR (2008) [7]

USA

I:63 C:67

69/61

53.5 years

HCC; MCC; GBC; MLT

71

Major hepatic resection

130

Acute normovolemic dilution

Control

Junrungsee S (2021) [17]

Thailand

I:59 C:61

74/46

56.6 years

HCC; ICC; GBC; MCC

83

Elective hepatectomy

None reported

Intrahepatic inferior vena cava clamping to low CVP

No IVC clamping

Kajikawa (1994) [6]

Japan

I:21 C:21

Not stated

Not stated

HCC

42

Liver resection

12

Autologous blood donation

Control

Kato M (2008) [32]

Japan

I:43 C:42

Not stated

66 years

PLC; GBC; ICC; MLT

Not stated

Liver resection

Not stated

Clamping the intrahepatic inferior vena cava

No IVC clamping

Matot I (2002) [33]

Israel

I:39 C:39

31/47

56.5 years

PLC; MLT

Not stated

Elective major hepatic resection (hepatectomy or extended hepatectomy)

78

Acute normovolemic dilution

Control

Pan YX (2020) [20]

China

I:73 C:73

125/21

54.5 years

HCC

59

Laparoscopic hepatectomy

Not stated

Intravenous use of vasoactive drugs to low CVP

Routine management

Ueno M (2017) [19]

Japan

I:45 C:45

65/25

70 years

HCC; GBC; MLT; ICC

Not stated

Liver resection

32

Clamping intrahepatic inferior vena cava to maintain the CVP ≤ 3 mmHg

Control

Wang WD (2006) [8]

China

I:25 C:25

40/10

45.7 years

HCC

29

Hepatectomy

17

Trendelenburg’s posture, nitroglycerine, isoflurane, limiting the volume and speed of infusion to low CVP

Control

Yao XH (2006) [21]

China

I:20

C:10

16/14

Not stated

PLC

Not stated

Hepatic resection

Not stated

1. ANH with hypotension

2. ANH without hypotension

Control

Yu L (2020) [18]

China

I:70 C:69

116/33

55.1 years

PLC; MLT

37

Elective partial hepatectomy

56

Administration

of nitroglycerin and esmolol using an

infusion pump to maintain a low CVP

Control

Zhow YM (2016) [34]

China

I:50 C:51

94/7

54 years

HCC

25

Major right hepatic resection

101

Intrahepatic inferior vena cava clamping

Control

  1. Abbreviations: HCC Hepatocellular carcinoma, PLC Primary liver carcinoma, MLT Metastatic liver tumor, ICC Intrahepatic cholangiocellular carcinoma, GBC Gallbladder carcinoma, MCC Metastasis of colorectal carcinoma