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Table 6 Effect size of intraoperative serum high mobility group box 1 (continuous variable) levels on pediatric acute respiratory distress syndrome in subgroups

From: Association between serum HMGB1 elevation and early pediatric acute respiratory distress syndrome: a retrospective study of pediatric living donor liver transplant recipients with biliary atresia in China

Characteristic

No. of participants

PARDS

  

OR(95% CI)

P

P for interaction

Graft cold ischemia time(min)

   

0.0118

 40–75

68

1.05 (0.78, 1.40)

0.7495

 

 76–98

71

2.20 (1.33, 3.05)

0.0009

 

 99–366

71

1.14 (0.90, 1.44)

0.2701

 

Intraoperative blood loss volume(mL)

   

0.4138

 50–250

60

1.34 (0.93, 1.93)

0.1160

 

 300–350

61

1.59 (1.11, 2.28)

0.0113

 

 400–1000

89

1.22 (1.02, 1.46)

0.0256

 

Pretransplant albumin(g/L)

   

0.8655

 23.7–32.6

68

1.30 (1.04, 1.61)

0.0199

 

 32.7–36.3

72

1.31 (1.01, 1.70)

0.0412

 

 36.4–49.4

70

1.18 (0.83, 1.66)

0.3536

 

Pretransplant total bilirubin(µmol/L)

   

0.1577

 3.15–184.8

70

1.18 (0.87, 1.62)

0.2877

 

 187.23–326

70

1.19 (0.88, 1.60)

0.2642

 

 327.5–862.7

70

1.67 (1.25, 2.24)

0.0006

 

Weight

   

0.0084

 4.5–6.47

70

1.46 (1.10, 1.93)

0.0080

 

 6.48–7.46

65

1.96 (1.27, 3.02)

0.0023

 

 7.5–14.5

75

0.99 (0.77, 1.27)

0.9505

 

Sex

   

0.1544

 Male

94

1.17 (0.97, 1.43)

0.1052

 

 Female

116

1.44 (1.14, 1.81)

0.0019

 

Age(month)

   

0.0835

 4.6–6.27

70

1.25 (0.97, 1.60)

0.0837

 

 6.33–8.8

70

1.68 (1.21, 2.32)

0.0020

 

 8.9–36.23

70

1.04 (0.77, 1.40)

0.8068

 
  1. Logistic regression was performed for subgroup analysis. Age (month), weight (kg), graft cold ischemia time (min), intraoperative blood loss volume (mL), pretransplant albumin (g/L), and pretransplant total bilirubin (µmol/L) were adjusted
  2. Abbreviations: PARDS, pediatric acute respiratory distress syndrome; OR, odds ratio; CI, confidence interval