Table 2 Baseline characteristics of the participants by intraoperative serum high mobility group box 1 tertiles
Characteristics | Serum HMGB1, pg/mL | p | ||
|---|---|---|---|---|
1st tertile (4.3–8.1 pg/mL) (n = 70) | 2nd tertile (8.2–10.6 pg/mL) (n = 69) | 3rd tertile (10.6–18.8 pg/mL) (n = 71) | ||
Recipient | Â | Â | Â | Â |
Intraoperative HMGB1: Median (IQR), pg/mL | 7.3 (6.5 to 7.7) | 9.3 (8.6 to 9.8) | 12.6 (11.9 to 14.0) | < 0.001 |
Sex, n (%) | Â | Â | Â | Â |
 Male | 39 (55.7) | 41 (59.4) | 36 (50.7) | 0.581 |
 Female | 31 (44.3) | 28 (40.6) | 35 (49.3) |  |
Age: Median (IQR), month | 7.8 (6.1 to 12.4) | 7.6 (6.0 to 9.9) | 6.5 (5.8 to 8.6) | 0.102 |
Weight: Median (IQR), kg | 7.0 (6.0 to 8.9) | 7.0 (6.3 to 8.0) | 6.7 (6.0 to 7.7) | 0.637 |
Pretransplant PELD scores: Median (IQR) | 16.0 (8.3 to 22.0) | 17.0 (11.0 to 24.0) | 21.0 (13.5 to 25.5) | 0.061 |
Pretransplant hemoglobin: Mean ± SD, g/L | 96.2 ± 12.4 | 95.3 ± 15.8 | 94.9 ± 15.2 | 0.858 |
Pretransplant creatinine: Median (IQR), µmol/L | 14.0 (12.0 to 16.0) | 13.0 (11.0 to 16.0) | 13.0 (11.8 to 17.0) | 0.398 |
Pretransplant albumin: Median (IQR), g/L | 34.7 (32.6 to 37.6) | 34.5 (31.7 to 38.6) | 33.70 (31.4 to 36.2) | 0.231 |
Pretransplant total bilirubin: Median (IQR), µmol/L | 209.99 (80.6 to 324.1) | 261.82 (157.8 to 337.9) | 315.32 (203.4 to 487.6) | 0.002 |
Pretransplant INR: Median (IQR) | 1.4 (1.1 to 1.7) | 1.4 (1.1 to 1.8) | 1.4 (1.2 to 1.9) | 0.251 |
Pretransplant WBC: Median (IQR), ×109 | 10.6 (7.7 to 14.4) | 12.0 (8.9 to 16.2) | 12.7 (9.0 to 18.5) | 0.244 |
Pretransplant lactic acid: Median (IQR), mmol/L | 3.4 (2.8 to 4.5) | 3.4 (2.7 to 4.2) | 3.5 (2.9 to 4.6) | 0.776 |
Pretransplant blood ammonia: Median (IQR), µmol/L | 63.5 (51.0 to 84.5) | 60.00 (47.0 to 79.0) | 56.0 (48.0 to 76.0) | 0.264 |
Surgery history, n (%) | Â | Â | Â | 0.911 |
 No | 3 (4.3) | 2 (2.9) | 4 (5.6) |  |
 Yes | 67(95.7) | 67(97.1) | 67(94.4) |  |
Pretransplant HMGB1: Median (IQR), pg/mL | 0.9 (0.5 to 1.3) | 0.9 (0.7 to 1.3) | 0.8 (0.5 to 1.2) | 0.472 |
Graft cold ischemia time: Median (IQR), min | 86.5 (71.0 to 99.0) | 83.0 (66.0 to 104.0) | 93.0 (77.5 to 121.5) | 0.015 |
Intraoperative blood loss volume: Median (IQR), mL | 300.0 (200.0 to 400.0) | 300.0 (200.0 to 400.0) | 400.0 (300.0 to 600.0) | < 0.001 |
Intraoperative anthepatic phase time: Median (IQR), min | 45.0 (39.0 to 57.0) | 41.0 (38.0 to 51.0) | 44.0 (37.0 to 54.0) | 0.245 |
Intraoperative freshplasma transfusions: Median (IQR), mL | 150.0 (0.0 to 400.0) | 200.0 (130.0 to 400.0) | 360.0 (200.0 to 400.0) | < 0.001 |
Intraoperative RBC transfusions: Median (IQR), in unit | 2.0 (2.0 to 2.0) | 2.0 (2.0 to 3.0) | 2.0 (2.0 to 4.0) | < 0.001 |
Intraoperative urine volume: Median (IQR), mL | 400.0 (300.0 to 600.0) | 400.0 (300.0 to 600.0) | 400.0 (240.0 to 600.0) | 0.853 |
Intraoperative infusion volume: Median (IQR), mL | 1307.5 (900.0 to 1669.0) | 1130.0 (830.0 to 1466.0) | 1117.5 (815.0 to 1434.0) | 0.101 |
Intraoperative surgery time: Median (IQR), min | 512.5 (455.0 to 553.0) | 475.0 (414.0 to 532.0) | 460.0 (412.5 to 527.5) | 0.015 |
Donor | Â | Â | Â | Â |
Age: Median (IQR), years | 31.6 (28.8 to 34.9) | 30.0 (26.5 to 35.2) | 30.0 (26.8 to 33.5) | 0.375 |
Sex, n (%) | Â | Â | Â | 0.309 |
Male Female | 38 (54.3) 32 (45.7) | 44 (63.8) 25 (36.2) | 47 (66.2) 24 (33.8) | Â |
BMI: Median (IQR) | 23.1 (21.2 to 24.8) | 22.9 (20.0 to 24.9) | 21.6 (19.6 to 24.7) | 0.221 |
Weight of graft: Median (IQR), g | 239.0 (212.0 to 272.0) | 240.0 (213.0 to 270.0) | 230.0 (200.0 to 263.5) | 0.510 |
GRWR: Mean ± SD, % | 3.4 ± 1.0 | 3.4 ± 0.8 | 3.4 ± 0.8 | 0.975 |