Risk-adjusted perioperative bridging anticoagulation reduces bleeding complications without increasing thromboembolic events in general and visceral surgery

Table 3 Postoperative complications and patient outcome

Characteristic, n (%)		Period 1 n = 263	Period 2 n = 271	p value¹
Postoperative bleeding²		58 (22.1)	28 (10.3)	< 0.001
within DOAC³		5 (21.7)	12 (8.3)	0.048
major		22 (8.4)	11 (4.1)	0.039
minor		36 (13.7)	17 (6.3)	0.004
Red blood cell transfusion		23 (8.7)	12 (4.4)	0.044
Thromboembolism		2 (0.8)	3 (1.1)	1
Clavien-Dindo⁴	Grade IIIa—V	61 (23.2)	66 (24.4)	0.753
Clavien-Dindo⁴	Grade IVa—V	18 (6.8)	16 (5.9)	0.656
Reoperation		40 (15.2)	42 (15.5)	0.926
In-hospital mortality		4 (1.5)	9 (3.3)	0.262
LOS, d, mean (95%CI)		10.5 (9.1–11.8)	10.0 (8.7–11.3)	0.63

¹p values of continuous outcomes were calculated by Welch test, p values of categorical outcomes were calculated by a two-sided χ²-test or, in case of categories with less than 5 subjects, by Fisher’s exact test
²according to the International Society on Thrombosis and Haemostasis
³percentages only within the group of patients receiving DOAC
⁴according to Clavien-Dindo classification
⁵postoperative length-of-stay

ISSN: 1471-2253