Table 3 Unadjusted and adjusted effect of PEEP on ICP and CPP
Variables | Unadjusted Analyses | Adjusted Analyses | ||
|---|---|---|---|---|
PEEP beta estimate (95% CI) | P value | PEEP beta estimate (95% CI) | P value | |
ICP | ||||
obese | 0.2 (0.06, 0.34) | 0.004 | 0.19 (0.05, 0.33) | 0.007 |
non-obese | 0.02 (-0.03, 0.06) | 0.423 | 0.02 (-0.03, 0.06) | 0.445 |
no LI | 0.04 (-0.02, 0.1) | 0.168 | 0.04 (-0.02, 0.1) | 0.165 |
mild LI | 0.17 (0.01, 0.33) | 0.035 | 0.16 (0.01, 0.32) | 0.038 |
moderate LI | 0 (-0.24, 0.23) | 0.974 | -0.02 (-0.24, 0.19) | 0.832 |
severe LI | 0.02 (-0.05, 0.09) | 0.586 | 0.02 (-0.05, 0.09) | 0.614 |
TBI | -0.03 (-0.09, 0.04) | 0.637 | -0.03 (-0.08, 0.03) | 0.529 |
non-TBI | 0.01 (-0.07, 0.09) | 0.539 | 0.01 (-0.06, 0.08) | 0.458 |
obese + no LI | 0.17 (0.02, 0.32) | 0.029 | 0.17 (0.01, 0.33) | 0.036 |
obese + mild LI | 0.1 (-0.14, 0.34) | 0.414 | 0.1 (-0.14, 0.35) | 0.421 |
obese + moderate LI | 0.29 (-0.11, 0.69) | 0.162 | 0.23 (-0.14, 0.61) | 0.216 |
obese + severe LI | 0.23 (-0.11, 0.57) | 0.179 | -0.02 (-0.64, 0.6) | 0.950 |
non-obese + no LI | 0.03 (-0.03, 0.08) | 0.354 | 0.03 (-0.03, 0.08) | 0.335 |
non-obese + mild LI | 0.21 (-0.01, 0.44) | 0.063 | 0.18 (-0.03, 0.39) | 0.093 |
non-obese + moderate LI | -0.17 (-0.43, 0.1) | 0.213 | -0.16 (-0.39, 0.07) | 0.183 |
non-obese + severe LI | 0.01 (-0.07, 0.09) | 0.758 | 0 (-0.07, 0.08) | 0.919 |
total | 0.04 (-0.003, 0.09) | 0.064 | 0.04 (-0.004, 0.09) | 0.071 |
CPP | ||||
obese | -0.12 (-0.44, 0.2) | 0.452 | -0.15 (-0.29, -0.01) | 0.036 |
non-obese | -0.09 (-0.21, 0.04) | 0.193 | -0.01 (-0.07, 0.05) | 0.717 |
no LI | -0.01 (-0.13, 0.1) | 0.827 | 0 (-0.07, 0.07) | 0.997 |
mild LI | -0.22 (-0.57, 0.12) | 0.208 | -0.08 (-0.26, 0.1) | 0.393 |
moderate LI | -0.26 (-0.84, 0.33) | 0.391 | 0 (-0.22, 0.21) | 0.988 |
severe LI | -0.18 (-0.28, -0.08) | < 0.001 | -0.07 (-0.18, 0.03) | 0.182 |
TBI | -0.11 (-0.32, 0.09) | 0.193 | -0.12 (-0.36, 0.12) | 0.407 |
non-TBI | -0.29 (-0.72, 0.14) | 0.262 | -0.17 (-0.59, 0.25) | 0.522 |
obese + no LI | 0.05 (-0.36, 0.45) | 0.819 | -0.11 (-0.28, 0.06) | 0.199 |
obese + mild LI | -0.49 (-1.03, 0.06) | 0.080 | -0.16 (-0.46, 0.13) | 0.280 |
obese + moderate LI | -0.31 (-1.07, 0.45) | 0.422 | -0.13 (-0.49, 0.24) | 0.508 |
obese + severe LI | -0.49 (-1.34, 0.36) | 0.259 | -0.18 (-0.76, 0.4) | 0.542 |
non-obese + no LI | -0.02 (-0.15, 0.1) | 0.741 | 0.02 (-0.06, 0.09) | 0.675 |
non-obese + mild LI | -0.07 (-0.53, 0.39) | 0.767 | -0.1 (-0.33, 0.12) | 0.358 |
non-obese + moderate LI | -0.22 (-1.03, 0.6) | 0.602 | 0 (-0.23, 0.23) | 0.983 |
non-obese + severe LI | -0.17 (-0.25, -0.08) | < 0.001 | -0.06 (-0.16, 0.05) | 0.274 |
total | -0.09 (-0.21, 0.03) | 0.140 | -0.03 (-0.09, 0.02) | 0.257 |