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Table 2 Clinical parameters between non-obese and obese

From: The effect of positive end-expiratory pressure on intracranial pressure in obese and non-obese severe brain injury patients: a retrospective observational study

 

Total observations

(n = 30,415)

Non-obese

(n = 19,566)

Obese

(n = 10,849)

P value

Cerebral parameters

  ICP (mmHg)

9 (5, 14)

9 (5, 13)

10 (6, 15)

< 0.001

  CPP (mmHg)

76 (68, 85)

76 (68, 85)

76 (67, 85)

0.006

Ventilation parameters

  PEEP (cmH2O)

5 (5, 8)

5 (5, 8)

5 (5, 8)

< 0.001

  Plateau Pressure (cmH2O)

18 (15, 20)

17 (15, 19)

19 (16, 22)

< 0.001

  Tidal Volume (ml)

500 (450, 550)

500 (450, 550)

520 (475, 580)

< 0.001

  Tidal Volume/PBW (ml/kg)

7.3 (6.5, 8.1)

7.3 (6.5, 8.0)

7.6 (6.8, 8.4)

< 0.001

  Respiratory Rate (bpm)

18 (17, 21)

18 (16, 21)

18 (17, 21)

< 0.001

  FiO2

40 (40, 49)

40 (40, 40)

40 (40, 50)

< 0.001

Laboratory parameters

  PaCO2 (mmHg)

36 (32, 40)

36 (31, 39)

37 (33, 41)

< 0.001

  PaO2 (mmHg)

149 (104, 208)

159 (114,216)

137 (95, 172)

< 0.001

  pH

7.39 (7.33, 7.43)

7.39 (7.33, 7.43)

7.39 (7.32, 7.43)

0.075

  PaO2/FiO2

344 (212, 421)

357 (242, 421)

308 (180, 413)

< 0.001

Hemodynamic parameters

  Heart Rate (bpm)

83 (72, 95)

84 (72, 97)

82 (72, 93)

< 0.001

  Systolic BP (mmHg)

132 (122, 145)

131 (121, 144)

135 (124, 147)

< 0.001

  Diastolic BP (mmHg)

66 (58, 72)

65 (57, 72)

66 (59, 73)

< 0.001

  Mean arterial BP (mmHg)

86 (79, 94)

86 (78, 93)

87 (79, 95)

< 0.001

  1. Data are median (interquartile range) or no./total (%)
  2. Each observation refers to a paired ICP and PEEP data point, not an individual patient
  3. BP blood pressure, bpm beat per minute, CPP cerebral perfusion pressure, FiO2 fraction of inspired oxygen, ICP intracranial pressure, PBW predicted body weight, PEEP positive end-expiratory pressure