Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial

Table 2 Adverse events observed during the procedure

	Group F	Group EL	Group EM	Group EH	χ²	P-value ^a,b
Sample size, n	45	45	44	44
Hypotension, n (%)	9 (20%)	0 (0%)^*	0 (0%)^*	0 (0%)^*	19.648	<0.001
Somatic motor reactions, n (%)	12 (26.7%)	8 (15.6%)	4 (9.1%)^*	2 (4.5%)^*#	10.254	0.016
Hypoxia, n (%)	5 (11.1%)	0 (0%)^*	1 (2.3%)^*	1 (2.3%)^*	8.622	0.035
Nausea and Vomiting, n (%)	1 (2.2%)	2 (4.4%)	1 (2.3%)	7 (15.9%)^*#$	7.493	0.038
Potential psychiatric symptoms, n (%)	0 (0%)	0 (0%)	1 (2.3%)	5(11.4%)^*#$	8.248	0.003

Abbreviations: SD Standard deviation, N number, Group F Fentanyl group, Group EL 0.2 mg/kg group Esketamine, Group EM 0.25 mg/kg Esketamine group, Group EH 0.3 mg/kg Esketamine group
^a P-value for group F compared with group EL, group EM and group EH. The symbol ^* indicates statistically significant difference compared with group F, ^# indicates statistically significant difference compared with group EL, ^$ indicates that the difference was statistically significant when compared with group EM
^b Chi-square test and Fisher’s exact test were used for data analysis

ISSN: 1471-2253