Fig. 3
From: Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression
Lidocaine promotes apoptosis of MCF-7 cells by inhibiting VDAC1 expression. A VDAC1 expression in different concentrations of MCF-7 cells was detected by immunofluorescence; B Effect of different concentrations of lidocaine on the activity of MCF-7 cells; C and D Western Blot measured the expression of VDAC1 and the expression of the pro-apoptotic protein Bcl-2 and the tumor suppressor gene p53 in different concentrations of lidocaine MCF-7 cells; E The cell cycle distribution of MCF-7 cells treated with various concentrations (0,1,3 mM) of lidocaine; F Lidocaine induced apoptosis in MCF-7 cells measured by flow cytometry. Compared with the 0 mM lidocaine group, * P < 0.05