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Table 3 Primary and Secondary Outcomes According to the Allocation Group and to the Type of Surgery

From: Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications

  Laparoscopic Surgery Open Surgery p for Interaction
Low Tidal Volume
(n = 158)
Conventional Tidal Volume
(n = 170)
Absolute Difference
(95% CI)
p value Low Tidal Volume
(n = 456)
Conventional Tidal Volume
(n = 422)
Absolute Difference
(95% CI)
p value
Primary outcome
  Delirium during hospital stay 13 (8.2) 15 (8.8) -0.60 (-6.74 to 5.61) 0.847 55 (12.1) 52 (12.3) -0.26 (-4.63 to 4.07) 0.906 0.930
Key secondary outcome
  Delirium during hospital stay 13 (8.2) 15 (8.8) -0.60 (-6.74 to 5.61) 0.847 55 (12.1) 52 (12.3) -0.26 (-4.63 to 4.07) 0.906 0.930
Secondary outcomes
  Number of doses of anxiolytic 3.0 (1.0—4.0) 2.5 (1.0—3.2) 0.19 (-2.82 to 3.19) 0.904 4.0 (2.0—8.0) 4.0 (1.0—11.0) -0.00 (-3.16 to 3.16) 0.999 0.864
  Number of doses of antipsychotic 3.0 (1.8—3.8) 2.0 (1.2—2.8) 1.00 (-3.62 to 5.62) 0.679 4.0 (2.0—10.5) 6.0 (3.0—11.0) -2.00 (-8.70 to 4.70) 0.562 0.526
  Total dose of antipsychotic 9.0 (3.8—13.4) 2.5 (2.0—3.8) 3.20 (-7.09 to 13.50) 0.552 9.4 (2.2—23.5) 12.0 (3.0—48.0) -1.96 (-29.20 to 25.27) 0.888 0.554
  1. Data are presented as median (quartile 25—quartile 75) or N (%)
  2. Absolute difference is risk difference for primary and key secondary outcomes and median difference for secondary outcomes