Table 3 Primary and Secondary Outcomes According to the Allocation Group and to the Type of Surgery
Laparoscopic Surgery | Open Surgery | p for Interaction | |||||||
|---|---|---|---|---|---|---|---|---|---|
Low Tidal Volume (n = 158) | Conventional Tidal Volume (n = 170) | Absolute Difference (95% CI) | p value | Low Tidal Volume (n = 456) | Conventional Tidal Volume (n = 422) | Absolute Difference (95% CI) | p value | ||
Primary outcome | |||||||||
Delirium during hospital stay | 13 (8.2) | 15 (8.8) | -0.60 (-6.74 to 5.61) | 0.847 | 55 (12.1) | 52 (12.3) | -0.26 (-4.63 to 4.07) | 0.906 | 0.930 |
Key secondary outcome | |||||||||
Delirium during hospital stay | 13 (8.2) | 15 (8.8) | -0.60 (-6.74 to 5.61) | 0.847 | 55 (12.1) | 52 (12.3) | -0.26 (-4.63 to 4.07) | 0.906 | 0.930 |
Secondary outcomes | |||||||||
Number of doses of anxiolytic | 3.0 (1.0—4.0) | 2.5 (1.0—3.2) | 0.19 (-2.82 to 3.19) | 0.904 | 4.0 (2.0—8.0) | 4.0 (1.0—11.0) | -0.00 (-3.16 to 3.16) | 0.999 | 0.864 |
Number of doses of antipsychotic | 3.0 (1.8—3.8) | 2.0 (1.2—2.8) | 1.00 (-3.62 to 5.62) | 0.679 | 4.0 (2.0—10.5) | 6.0 (3.0—11.0) | -2.00 (-8.70 to 4.70) | 0.562 | 0.526 |
Total dose of antipsychotic | 9.0 (3.8—13.4) | 2.5 (2.0—3.8) | 3.20 (-7.09 to 13.50) | 0.552 | 9.4 (2.2—23.5) | 12.0 (3.0—48.0) | -1.96 (-29.20 to 25.27) | 0.888 | 0.554 |