Table 3 Toxicokinetic parameters of ropivacaine in the plasma of rats
From: Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot
Dose(mg/kg) | t1/2(h) | Tmax(h) | Cmax(μg/mL) | AUC(0–24 h) (h·µg/mL) | AUCinf(h·µg/mL) |
|---|---|---|---|---|---|
75 | 3.60 ± 0.68 | 1.21 ± 0.68 | 1.24 ± 0.59 | 11.65 ± 1.58 | 11.77 ± 1.64 |
150 | 7.87 ± 1.58 | 0.71 ± 0.33 | 1.58 ± 0.87 | 24.14 ± 3.48 | 25.34 ± 4.88 |
300 | 7.01 ± 1.20 | 8.00 ± 8.29 | 2.84 ± 1.02 | 107.80 ± 12.98 | 148.18 ± 88.19 |