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Table 2 Effects of the subcutaneous injection of RODD on major blood biochemical indexes in rats

From: Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot

Group

Sex

Total protein

(g/L)

Albumin

(g/L)

Albumin, albumin

/globulin ratio

Alanine amino transferase (U/L)

Triglyceride

(mmol/L)

Saline

M

50.2 ± 3.1

30.4 ± 2.1

1.54 ± 0.09

38.8 ± 3.9

0.50 ± 0.10

F

59.4 ± 4.2

35.4 ± 2.1

1.48 ± 0.08

24.6 ± 4.0

0.50 ± 0.07

Solvent

M

53.0 ± 2.5

28.6 ± 1.7

1.18 ± 0.08

36.6 ± 9.6

0.45 ± 0.11

F

54.4 ± 1.0

30.4 ± 1.8

1.28 ± 0.08

31.8 ± 4.4

0.55 ± 0.16

RODD (mg/ kg)

 75

M

51.2 ± 1.3

28.0 ± 1.7

1.22 ± 0.15

37.6 ± 5.8

0.54 ± 0.15

F

56.8 ± 0.8

31.6 ± 1.10

1.26 ± 0.09

29.8 ± 2.9

0.39 ± 0.10

 150

M

54.0 ± 2.1

29.2 ± 0.4

1.20 ± 0.07

36.4 ± 4.6

0.44 ± 0.11

F

58.6 ± 2.1

32.4 ± 1.1

1.24 ± 0.05

24.4 ± 4.3

0.59 ± 0.15

 300

M

56.8 ± 1.7

29.3 ± 1.3

1.05 ± 0.06

44.5 ± 8.4

0.40 ± 0.06

F

61.0 ± 9.5

33.7 ± 5.1

1.23 ± 0.06

44.0 ± 19.1

1.68 ± 1.06

P value

 Solvent vs Saline

M

0.16

0.17

0.00**

0.65

0.44

F

0.04*

0.00**

0.01*

0.03*

0.56

 75 mg/kg vs Saline

M

0.53

0.08

0.00**

0.71

0.66

F

0.21

0.01*

0.00**

0.04*

0.10

 150 mg/kg vs Saline

M

0.05

0.24

0.00**

0.40

0.37

F

0.71

0.02*

0.00**

0.94

0.27

 300 mg/kg vs Saline

M

0.01**

0.37

0.00**

0.21

0.13

F

0.75

0.51

0.00**

0.04*

0.04*

  1. Results are presented as mean ± SD, n = 15/sex/group
  2. M Male, F Female
  3. Mean value indicates a significant difference (*P < 0.05, **P < 0.01) compared to Saline.