From: Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot
Group | Sex | Total protein (g/L) | Albumin (g/L) | Albumin, albumin /globulin ratio | Alanine amino transferase (U/L) | Triglyceride (mmol/L) |
---|---|---|---|---|---|---|
Saline | M | 50.2 ± 3.1 | 30.4 ± 2.1 | 1.54 ± 0.09 | 38.8 ± 3.9 | 0.50 ± 0.10 |
F | 59.4 ± 4.2 | 35.4 ± 2.1 | 1.48 ± 0.08 | 24.6 ± 4.0 | 0.50 ± 0.07 | |
Solvent | M | 53.0 ± 2.5 | 28.6 ± 1.7 | 1.18 ± 0.08 | 36.6 ± 9.6 | 0.45 ± 0.11 |
F | 54.4 ± 1.0 | 30.4 ± 1.8 | 1.28 ± 0.08 | 31.8 ± 4.4 | 0.55 ± 0.16 | |
RODD (mg/ kg) | ||||||
75 | M | 51.2 ± 1.3 | 28.0 ± 1.7 | 1.22 ± 0.15 | 37.6 ± 5.8 | 0.54 ± 0.15 |
F | 56.8 ± 0.8 | 31.6 ± 1.10 | 1.26 ± 0.09 | 29.8 ± 2.9 | 0.39 ± 0.10 | |
150 | M | 54.0 ± 2.1 | 29.2 ± 0.4 | 1.20 ± 0.07 | 36.4 ± 4.6 | 0.44 ± 0.11 |
F | 58.6 ± 2.1 | 32.4 ± 1.1 | 1.24 ± 0.05 | 24.4 ± 4.3 | 0.59 ± 0.15 | |
300 | M | 56.8 ± 1.7 | 29.3 ± 1.3 | 1.05 ± 0.06 | 44.5 ± 8.4 | 0.40 ± 0.06 |
F | 61.0 ± 9.5 | 33.7 ± 5.1 | 1.23 ± 0.06 | 44.0 ± 19.1 | 1.68 ± 1.06 | |
P value | ||||||
Solvent vs Saline | M | 0.16 | 0.17 | 0.00** | 0.65 | 0.44 |
F | 0.04* | 0.00** | 0.01* | 0.03* | 0.56 | |
75 mg/kg vs Saline | M | 0.53 | 0.08 | 0.00** | 0.71 | 0.66 |
F | 0.21 | 0.01* | 0.00** | 0.04* | 0.10 | |
150 mg/kg vs Saline | M | 0.05 | 0.24 | 0.00** | 0.40 | 0.37 |
F | 0.71 | 0.02* | 0.00** | 0.94 | 0.27 | |
300 mg/kg vs Saline | M | 0.01** | 0.37 | 0.00** | 0.21 | 0.13 |
F | 0.75 | 0.51 | 0.00** | 0.04* | 0.04* |