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Table 1 Effects of the subcutaneous injection of RODD on major blood cells in rats

From: Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot

Dose (mg/kg)

Sex

Neutrophils(× 109/L)

Lymphocyte(× 109/L)

Mononuclear(× 109/L)

Saline

M

1.02 ± 0.34

9.01 ± 1.90

0.14 ± 0.02

F

0.47 ± 0.12

8.99 ± 2.62

0.12 ± 0.04

Solvent

M

1.88 ± 0.45

9.32 ± 2.43

0.26 ± 0.08

F

0.65 ± 0.22

8.10 ± 1.86

0.20 ± 0.08

RODD

 75 mg/kg

M

1.54 ± 1.51

11.25 ± 1.72

0.25 ± 0.16

F

0.91 ± 0.19

8.55 ± 1.54

0.19 ± 0.03

 150 mg/kg

M

1.78 ± 0.38

8.92 ± 1.56

0.23 ± 0.06

F

1.12 ± 0.43

9.28 ± 1.98

0.18 ± 0.06

 300 mg/kg

M

1.58 ± 0.76

9.91 ± 3.39

0.20 ± 0.03

F

2.53 ± 1.63

3.40 ± 2.06

0.38 ± 0.14

P value

 Solvent vs Saline

M

0.01*

0.82

0.01*

F

0.16

0.55

0.1

 75 mg/kg vs Saline

M

0.48

0.09

0.16

F

0.00**

0.75

0.02*

 150 mg/kg vs Saline

M

0.01*

0.94

0.01*

F

0.01*

0.85

0.10

 300 mg/kg vs Saline

M

0.18

0.63

0.00**

F

0.02*

0.02*

0.01*

  1. Results are presented as mean ± SD, n = 15/sex/group
  2. M Male, F Female
  3. Mean value indicates a significant difference (*P < 0.05, **P < 0.01) compared to Saline