From: Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot
Dose (mg/kg) | Sex | Neutrophils(× 109/L) | Lymphocyte(× 109/L) | Mononuclear(× 109/L) |
---|---|---|---|---|
Saline | M | 1.02 ± 0.34 | 9.01 ± 1.90 | 0.14 ± 0.02 |
F | 0.47 ± 0.12 | 8.99 ± 2.62 | 0.12 ± 0.04 | |
Solvent | M | 1.88 ± 0.45 | 9.32 ± 2.43 | 0.26 ± 0.08 |
F | 0.65 ± 0.22 | 8.10 ± 1.86 | 0.20 ± 0.08 | |
RODD | ||||
75 mg/kg | M | 1.54 ± 1.51 | 11.25 ± 1.72 | 0.25 ± 0.16 |
F | 0.91 ± 0.19 | 8.55 ± 1.54 | 0.19 ± 0.03 | |
150 mg/kg | M | 1.78 ± 0.38 | 8.92 ± 1.56 | 0.23 ± 0.06 |
F | 1.12 ± 0.43 | 9.28 ± 1.98 | 0.18 ± 0.06 | |
300 mg/kg | M | 1.58 ± 0.76 | 9.91 ± 3.39 | 0.20 ± 0.03 |
F | 2.53 ± 1.63 | 3.40 ± 2.06 | 0.38 ± 0.14 | |
P value | ||||
Solvent vs Saline | M | 0.01* | 0.82 | 0.01* |
F | 0.16 | 0.55 | 0.1 | |
75 mg/kg vs Saline | M | 0.48 | 0.09 | 0.16 |
F | 0.00** | 0.75 | 0.02* | |
150 mg/kg vs Saline | M | 0.01* | 0.94 | 0.01* |
F | 0.01* | 0.85 | 0.10 | |
300 mg/kg vs Saline | M | 0.18 | 0.63 | 0.00** |
F | 0.02* | 0.02* | 0.01* |