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Table 2 Echocardiographic parameters, mean arterial blood pressure, natriuretic peptides, high-sensitive troponin in patients without or with grade 1–3 diastolic dysfunction established by comprehensive and simplified assessment

From: Pre-operative point-of-care assessment of left ventricular diastolic dysfunction, an observational study

Diastolic dysfunction (DD)

No DD

Grade 1

Grade 2

Grade 3

p-value

Comprehensive assessment

 Number of patients

22 (23)

22 (23)

43 (45)

9 (9)

NA

 e’ mean (cm s−1)

11.1 ± 3.5

6.0 ± 1.5

6.9 ± 2.0

7.7 ± 2.9

< 0.001

 e’ lateral (cm s− 1)

12.7 ± 4.5

6.8 ± 2.0

7.7 ± 2.5

9.6 ± 4.6

< 0.001

 e’ septal (cm s− 1)

9.5 ± 3.2

5.2 ± 1.0

6.2 ± 1.6

5.8 ± 1.6

< 0.001

 E/e’ mean

7.3 ± 1.7

11.3 ± 4.6

12.8 ± 4.5

15.4 ± 4.6

< 0.001

 E/A ratio

1.2 ± 0.4

0.7 ± 0.1

0.98 ± 0.2

1.5 ± 0.5

< 0.001

 IVRT (ms)

71 ± 15

94 ± 15

86 ± 16

79 ± 25

< 0.001

 TRV > 2.8 m s−1

0 (0)

3 (13.6)

4 (9.3)

4 (44.4)

0.005

 LAI (mL m−2)

23.9 ± 6.5

30.9 ± 10.6

31.1 ± 9.9

39.8 ± 19.1

0.002

 LVEF (%)

58 ± 4

53 ± 10

56 ± 8

51 ± 14

0.081

 MAP (mmHg)

104 ± 14

106 ± 12

109 ± 12.4

108 ± 21.7

0.567

 Heart frequency/min

68 ± 12

72 ± 14

69 ± 10

72 ± 15

0.539

 NT-proBNP (ng L−1)

65 [69]

155 [534]

86 [166]

817 [1154]

< 0.001*

 hs-TnI (ng L1)

4.9 ± 2.4

6.2 ± 3.2

7.8 ± 4.4

12.9 ± 10.9

0.001

Simplified assessment

 Number of patients

27 (28.1)

8 (8.4)

36 (38.3)

24 (25)

NA

 e’ mean (cm s−1)

11.0 ± 3.3

7.6 ± 0.8

6.8 ± 1.3

5.3 ± 1.2

< 0.001

 e’ lateral (cm s−1)

12.9 ± 4.4

8.8 ± 1.0

7.6 ± 1.8

5.8 ± 1.4

< 0.001

 e’ septal (cm s−1)

9.2 ± 2.9

6.3 ± 1.2

5.9 ± 1.1

4.9 ± 1.1

< 0.001

 E/e’ mean

7.9 ± 2.7

7.4 ± 0.8

10.9 ± 1.5

17.6 ± 4.2

< 0.001

 E/A ratio

1.2 ± 4.0

0.9 ± 0.4

0.9 ± 0.2

1.0 ± 0.2

< 0.001

 IVRT (ms)

74 ± 15

92 ± 14

86 ± 18

89 ± 19

0.011

 TRV > 2.8 m s−1

1 (3)

0 (0)

4 (11)

5 (21)

0.163

 LAI (ml m−2)

27.6 ± 11.9

23.2 ± 8.4

28.9 ± 9.5

36.0 ± 12.3

0.014

 LVEF (%)

56 ± 8

56 ± 8

55 ± 8

55 ± 10

0.986

 MAP (mmHg)

99 ± 15

110 ± 5

109 ± 14

111 ± 10

0.006

 Heart frequency (min−1)

68 ± 11

69 ± 11

71 ± 12

68 ± 8

0.512

 NT-proBNP (ng L1)

65 [71]

75 [200]

98 [198]

198 [560]

0.007*

 hs-TnI (ng L−1)

5.5 ± 4.5

4.9 ± 3.4

7.2 ± 5.4

8.3 ± 5.6

0.151

  1. Values are mean ± SD, number of patients (% of overall) or median and [interquartile range] when appropriate
  2. Abbreviations: IVRT left ventricular isovolumic relaxation time, LVEF left ventricular ejection fraction, hs-TnI high-sensitive troponin I, LAI left atrial volume index, MAP mean arterial blood pressure, NA not applicable, NT-proBNP N-terminal prohormone of brain natriuretic peptide, TRV tricuspid regurgitation velocity
  3. P values are ANOVA, Kruskal-Wallis test (*) or Chi-Square test
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BMC Anesthesiology

ISSN: 1471-2253

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