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Table 1 Patient characteristics, medications and type of surgery in all patients, and comparing those with and without left ventricular diastolic dysfunction established by comprehensive assessment

From: Pre-operative point-of-care assessment of left ventricular diastolic dysfunction, an observational study

 

Overall

No diastolic dysfunction

Diastolic dysfunction

p-value

Number of patients

96

22

74

 

Age (years)

63 ± 12

51 ± 13

67 ± 9

< 0.001

Body mass index (kg m−2)

27 ± 4

25 ± 3

27 ± 4

0.041

Female sex, n (%)

84 (88)

17 (77)

68 (92)

0.017

Smoker, n (%)

21 (22)

1 (5)

20 (27)

0.025

MET < 4

25 (26)

2 (9)

23 (31)

0.039

ASA-PS III

28 (29)

1 (5)

27 (36)

0.004

NYHA (0)

60 (63)

22 (100)

0 (0)

< 0.001*

NYHA (I)

8 (8.3)

0 (0)

8 (11)

0.192*

NYHA (II)

6 (6)

0 (0)

6 (8)

0.331*

NYHA (III)

22 (23)

0 (0)

22 (30)

0.003*

NT-proBNP (ng L− 1)

90 [197]

65 [69]

128 [299]

0.001*

hs-TnI (ng L− 1)

6.8 ± 5.2

4.9 ± 2.4

7.4 ± 5.6

0.004

Haemoglobin (g LL1)

134 ± 15

139 ± 15

132 ± 14

0.081

Creatinine (μmol L−1)

87 ± 93

68 ± 16

92 ± 103

0.316

eGFR (mL/min/L.73m2)

70 ± 19

82 ± 10

67 ± 20

0.003

Co-morbidities

    

 Hypertension

67 (70)

11 (50)

57 (77)

0.014

 Renal failure

21 (23)

0 (0)

21 (28)

< 0.001

 Angina pectoris

14 (15)

0 (0)

14 (19)

0.027

 Bronchial asthma

17 (18)

0 (0)

17 (23)

0.013

 COPD

12 (13)

1 (5)

11 (15)

0.199

 Diabetes mellitus

9 (9)

2 (9)

7 (9)

0.958

Medications

 Beta-blockers

33 (34)

2 (9)

31 (42)

0.004

 Calcium channel blockers

24 (25)

3 (14)

21 (28)

0.161

 ACE- inhibitors

17 (18)

2 (9)

15 (20)

0.228

 Angiotensin receptor blockers

20 (21)

2 (9)

18 (24)

0.122

 Diuretics

26 (27)

0 (0)

26 (35)

0.001

 Nitroglycerine

9 (9)

0 (0)

9 (12)

0.086

Combination therapy*

36 (38)

2 (9)

34 (46)

0.002

Type of surgery

 Breast

65 (68)

16 (73)

49 (66)

0.566

 Thyroid

16 (17)

3 (14)

13 (18)

0.664

 Minor GI

15 (16)

3 (14)

12 (16)

0.770

  1. Values are mean ± SD, number of patients (% of overall) or median and [interquartile range] when appropriate. To evaluate differences between categorical variables Chi2-test or Fischer’s Exact test (*) was used, and for continuous variables student’s T-test or Mann-Whitney U-test (*) was used. Abbreviations: ACE, angiotensin converting enzyme; COPD, chronic obstructive pulmonary disease; GI, gastrointestinal; combination therapy*, beta-blockers, calcium channel blockers, ACE-inhibitors and/or angiotensin receptor blockers, diuretics; ARB, angiotensin receptor blockers; ASA-PS, American Society of Anesthesiologists Physical Status score; NYHA, New York Heart Association functional classification