| No Sedation | Midazolam | Propofol | Dexmedetomidine | P value |
---|---|---|---|---|---|
Number of Patients | 5 | 11 | 13 | 13 | Â |
Age (years, Mean ± SD) | 65.8 ± 7.4 | 63.3 ± 13.5 | 61.5 ± 14.2 | 62.8 ± 11.7 | 0.94 |
Gender | |||||
 Male | 1 | 6 | 7 | 6 | 0.85 |
 Female | 4 | 5 | 6 | 7 |  |
Hunt-Hess Scale | |||||
 III | 4 | 6 | 8 | 9 | 0.76 |
 IV | 1 | 5 | 5 | 4 |  |
Fisher Grade | |||||
 2 | 1 | 1 | 2 | 2 | 0.94 |
 3 ~ 4 | 4 | 10 | 11 | 11 |  |
WFNS SAH grading scale | |||||
 II | 3 | 2 | 4 | 4 | 0.42 |
 III ~ V | 2 | 9 | 9 | 9 |  |
Glasgow Outcome Scale | |||||
 Poor (1 ~ 4) |  | 8 | 9 | 9 | 0.98 |
 Good (5) |  | 3 | 4 | 4 |  |
RASS Before Sedation | |||||
  + 2 | 2 | 3 | 6 | 7 | 0.92 |
  + 3 | 2 | 6 | 5 | 4 |  |
  + 4 | 1 | 2 | 2 | 2 |  |
RASS After Sedation | |||||
  + 1 |  | 3 | 5 | 6 | 0.81 |
 0 |  | 5 | 4 | 5 |  |
 -1 |  | 3 | 4 | 2 |  |
Other Pharmacological Interventions | |||||
 Opioid Analgesics | 2 | 2 | 4 | 4 | 0.76 |
 Non-Opioid Analgesics | 2 | 2 | 4 | 4 | 0.76 |
 Mannitol | 2 | 6 | 9 | 8 | 0.55 |
 Hyperosmotic Saline | 2 | 7 | 7 | 7 | 0.79 |
 Insulin | 3 | 9 | 8 | 10 | 0.31 |
 Antihypertensive Agents | 3 | 9 | 10 | 11 | 0.22 |
 Vasoactive Agents | 2 | 10 | 10 | 9 | 0.15 |
Comorbidity | |||||
 Acute heart failure | 2 | 7 | 7 | 7 | 0.79 |
 Secondary Hypopituitarism | 3 | 7 | 6 | 9 | 0.35 |
 Hypertension | 1 | 2 | 4 | 3 | 0.90 |
 History of stroke or TIA | 0 | 3 | 4 | 4 | 0.49 |