Fig. 2From: Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort studyMidazolam altered CSF metabolome in SAH patients. A Overview of CSF metabolome in midazolam and control groups: 2-dimension score plot. 0, control; 1; midazolam; Component 1 and 2, dimensions of the PLS-DA model. Pathway analysis (B) and metabolite set enrichment analysis (C) presented the most influenced metabolic pathway by midazolam. Significantly altered metabolites were listed in (D), left column: control; right column: midazolam; red arrow: trend; *: statistical significance. E CSF biomarker of midazolam sedation, with ROC curve and cut-off valueBack to article page