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Table 5 Comparison of doses, patient characteristics, and pharmacokinetic parameters of cisatracurium in critically ill patients between studies

From: Pharmacokinetics and pharmacodynamics studies of a loading dose of cisatracurium in critically ill patients with respiratory failure

 

Our study

Liu et al.13

Boyd et al.7

Cisatracurium dose

0.2 mg/kg

0.1 mg/kg

0.1 mg/kg of an IV bolus (if necessary) and an infusion of 0.18 mg/kg/h

Characteristics of the patients

Critically ill patients with respiratory failure or ARDS (n=10)

Critically ill patients with severe sepsis (n=8)

Critically ill patients receiving mechanical ventilation (n=6)

Severity score: APACHE II (mean ±SD)

25 ± 8

11.9 ± 3.7

15 ± 6.7

Model

1-compartment model

1-compartment model

2-compartment model with elimination from the central compartment

PK parameters

-

-

-

- Vdss

- 0.11 ± 0.04 L/kg

- 0.111 ± 0.07 L/kg

- 0.32 ± 0.15 L/kg

- CL

- 2.74 ± 0.87 ml/min/kg (0.16 ± 0.05 L/h/kg)

- 5.23 ± 1.8 ml/min/kg (0.31 ± 0.11 L/h/kg)

- 7.9 ± 2.7 ml/min/kg (0.31 ± 0.11 L/h/kg)

  1. APACHE Acute Physiology and Chronic Health Evaluation, ARDS Acute respiratory distress syndrome, CL Clearance, Vdss Volume of distribution at steady state