Our study | Liu et al.13 | Boyd et al.7 | |
---|---|---|---|
Cisatracurium dose | 0.2 mg/kg | 0.1 mg/kg | 0.1 mg/kg of an IV bolus (if necessary) and an infusion of 0.18 mg/kg/h |
Characteristics of the patients | Critically ill patients with respiratory failure or ARDS (n=10) | Critically ill patients with severe sepsis (n=8) | Critically ill patients receiving mechanical ventilation (n=6) |
Severity score: APACHE II (mean ±SD) | 25 ± 8 | 11.9 ± 3.7 | 15 ± 6.7 |
Model | 1-compartment model | 1-compartment model | 2-compartment model with elimination from the central compartment |
PK parameters | - | - | - |
- Vdss | - 0.11 ± 0.04 L/kg | - 0.111 ± 0.07 L/kg | - 0.32 ± 0.15 L/kg |
- CL | - 2.74 ± 0.87 ml/min/kg (0.16 ± 0.05 L/h/kg) | - 5.23 ± 1.8 ml/min/kg (0.31 ± 0.11 L/h/kg) | - 7.9 ± 2.7 ml/min/kg (0.31 ± 0.11 L/h/kg) |