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Table 4 Correlations between the pharmacokinetic data and patient factors

From: Pharmacokinetics and pharmacodynamics studies of a loading dose of cisatracurium in critically ill patients with respiratory failure

Patient factor

Cisatracurium plasma concentration

PK parameters of cisatracurium

M1

M30

kel

t1/2

Albumin level

Correlation

-0.745

-0.683

-0.646

0.527

p value (95%CI)

0.013* (-0.935 to -0.218)

0.042* (-0.917 to -0.094)

0.044* (-0.906 to -0.028)

0.177 (-0.153 to 0.868)

pCO2

Correlation

-0.498

-0.192

-0.699

0.778

p -value (95%CI)

0.143 (-0.498 to 0.191)

0.620 (-0.733 to 0.497)

0.024* (-0.922 to -0.124)

0.008* (0.291 to 0.944)

Respiratory alkalosis

Correlation

0.485

0.053

0.636

-0.672

p -value (95%CI)

0.155 (-0.152 to 0.890)

0.892 (-0.554 to 0.830)

0.048* (0.044 to 0.909)

0.033* (-0.931 to -0.188)

  1. *statistically significant difference p value < 0.05
  2. kel, elimination rate constant; M1, concentration of cisatracurium 1 minute after cisatracurium administration; M30, cisatracurium plasma concentration 30 minutes after cisatracurium administration; t1/2, elimination half-life; pCO2, partial pressure of carbon dioxide