Pharmacokinetics and pharmacodynamics studies of a loading dose of cisatracurium in critically ill patients with respiratory failure

Table 3 Pharmacokinetic parameters and pharmacodynamic responses to 0.2 mg/kg of cisatracurium (N=10)

Subject No.	Pharmacokinetic parameters^a							Pharmacodynamic response
	Pharmacokinetic parameters^a							Clinical assessment	TOF monitoring
	C_max (ng/ml)	Vd_ss (L)	Vd_ss (L/kg)	CL (ml/min)	k_el (min^-1)	t_1/2 (min)	AUC_all (ng·h/ml)	Groups of time to patient-ventilator synchrony^b	Groups of time to a TOF of 0/4^b	Time to a TOF of 0/4 (min)	TOF site
1	2115.50	5.67	0.09	162.14	0.03	24.25	1233.50	moderate	immediate	2	FN
2	3204.63	4.37	0.06	227.16	0.05	13.33	1027.19	delayed	immediate	1	UN
3	1339.09	7.47	0.15	177.40	0.02	29.18	939.48	moderate	moderate	5	UN
4	1321.15	10.60	0.15	290.34	0.03	25.30	803.67	immediate	moderate	6	UN
5	3028.18	3.96	0.06	68.60	0.02	40.04	2915.56	moderate	moderate	7	UN
6	2613.11	2.68	0.08	92.49	0.03	20.07	1261.34	moderate	delayed	13	UN
7	1399.61	7.14	0.16	83.40	0.01	59.38	1998.44	moderate	delayed	12	UN
8	1729.48	6.94	0.12	139.86	0.02	34.39	1429.99	immediate	immediate	4	UN
9	1344.94	7.44	0.15	164.29	0.02	31.37	1014.45	moderate	moderate	5	FN
10	3204.06	3.43	0.06	139.22	0.04	17.09	1316.82	moderate	moderate	5	UN
Mean ± SD	2129.97 ± 812.32	5.97 ± 2.41	0.11 ± 0.04	154.49 ± 67.61	0.03 ± 0.01	29.44 ± 13.25	1394.04 ± 629.36

^aPharmacokinetic parameter estimation by one-compartmental analysis
^bPatients were classified by time to patient-ventilator synchrony and a TOF 0/4 into the following 3 groups: 1) immediate, less than 5 minutes; 2) moderate, 5 to 10 minutes; and 3) delayed, more than 10 minutes
AUC_all Area under the curve from the time of dosing to the time of the last observation, C_max The maximal drug concentration in plasma, CL Clearance, k_el Elimination rate constant, t_1/2 Elimination half-life, Vd_ss Volume of distribution at steady state, TOF Train-of-four, FN Facial nerve, UN Ulnar nerve

ISSN: 1471-2253