Hemodynamic variables | Usual care group (n = 42) | VAC-optimized group (n = 40) | P value a | P value b | ||
---|---|---|---|---|---|---|
0 h | 6 h | 0 h | 6 h | |||
HR (beats/min) | 109 ± 19 | 90 ± 11* | 113 ± 20 | 94 ± 10* | 0.328 | 0.104 |
CVP (mmHg) | 8 ± 3 | 10 ± 2* | 9 ± 3 | 9 ± 2 | 0.206 | 0.016 |
SAP (mmHg) | 92 ± 6 | 124 ± 11* | 90 ± 5 | 114 ± 10* | 0.118 | < 0.001 |
DAP (mmHg) | 44 ± 6 | 63 ± 7* | 43 ± 4 | 63 ± 7* | 0.364 | 0.949 |
MAP (mmHg) | 60 ± 5 | 83 ± 8* | 58 ± 4 | 80 ± 7* | 0.175 | 0.063 |
SV (mL) | 44 ± 6 | 48 ± 7* | 44 ± 4 | 49 ± 5* | 0.832 | 0.445 |
LVEDV (mL) | 93 ± 11 | 96 ± 11* | 96 ± 12 | 98 ± 11* | 0.323 | 0.449 |
LVESV (mL) | 49 ± 7 | 48 ± 5 | 50 ± 9 | 49 ± 7* | 0.288 | 0.505 |
LVEF (%) | 48 ± 4 | 50 ± 3* | 46 ± 5 | 50 ± 4* | 0.161 | 0.806 |
Cardiac index (L/min/m2) | 2.9 ± 0.7 | 2.6 ± 0.4* | 3.1 ± 0.6 | 2.9 ± 0.4* | 0.216 | 0.006 |
Ea (mmHg/mL) | 1.90 ± 0.19 | 2.35 ± 0.33* | 1.89 ± 0.15 | 2.12 ± 0.24* | 0.320 | < 0.001 |
Ees (mmHg/mL) | 1.32 ± 0.14 | 1.81 ± 0.26* | 1.28 ± 0.12 | 1.95 ± 0.32* | 0.244 | 0.037 |
Ea/Ees ratio | 1.45 ± 0.16 | 1.30 ± 0.11* | 1.46 ± 0.10 | 1.10 ± 0.15* | 0.915 | < 0.001 |
Lactate level (mmol/L) | 3.1 (2.1, 4.4) | 2.9 (2.0, 4.3)* | 2.8 (2.1, 4.2) | 2.0 (1.1, 2.8)* | 0.305 | 0.007 |