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Table 1 Patient, perioperative characteristics and outcomes

From: Opioid-free versus opioid-based anesthesia in pancreatic surgery

Characteristic

Total (n = 77)

OBA (n = 42)

OFA (n = 35)

P

Demographic Features

Age (years)

67 [27–85]

68 [27–85]

66 [39–81]

0.66

Female

30 (39%)

20 (47.6%)

10 (28.6%)

0.23

BMI (kg/m2)

27 [18–39]

27 [18–39]

27 [20–36]

0.44

Perioperative Factors

Procedures

  Pancreaticoduodenectomy

54 (70.1%)

31 (73.8%)

23 (65.7%)

0.96

  Distal Pancreatectomy

21 (27.3%)

10 (23.8%)

11 (31.4%)

  Other

2 (2.6%)

1 (2.4%)

1 (2.9%)

Operative time (minutes)

360 [103–660]

359 [166–660]

364 [103–544]

0.8

Atropine

7 (9.1%)

5 (11,9%)

2 (5,7%)

0.14

Norepinephrine (\(\upmu\) g/kg/min)

0.043 [0–0.2]

0.049 [0–0.2]

0.037 [0–0.11]

0.73

Blood loss (ml)

625 [50–3400]

700 [100–2600]

490 [50–3400]

0.59

Time to extubation (minutes)

7.0 [1.5–47]

7.0 [1.5–42]

7.5 [2–47]

0.88

Time to PACU discharge (Hours)

18.2 [7.1–21.7]

19.3 [7.1–20.9]

18.3 [7.9–21.7]

0.94

Length of stay (days)

12 [6–46]

14 [7–46]

10 [6–16]

 < 0.001***

Index Complications

Clavien-Dindo

  None

7 (9.0%)

3 (7%)

4 (11.4%)

0.86

  Grade I

31 (39.7%)

13 (30.2%)

18 (51.4%)

  Grade II

21 (26.9%)

15 (34.9%)

6 (17.1%)

  Grade III

11 (14.1%)

7 (16.3%)

4 (11.4%)

  Grade IV

5 (6.4%)

3 (7.0%)

2 (5.7%)

  Grade V

3 (3.9%)

2 (4.7%)

1 (2.9%)

CCI

20.9 [0–100]

20.9 [0–100]

0 [0–100]

0.03*

POPF

  None

63 (81.8%)

33 (78.5%)

30 (85.7%)

0.76

  Grade A

4 (5.2%)

2 (4.8%)

2 (5.7%)

  Grade B

9 (11.7%)

7 (16.7%)

2 (5.7%)

  Grade C

1 (1.3%)

0 (0%)

1 (2.9%)

DGE

  None

66 (85.7%)

32 (76.2%)

34 (97.1%)

0.31

  Grade A

2 (2.6%)

2 (4.8%)

0 (0%)

  Grade B

7 (9.1%)

6 (14.2%)

1 (2.9%)

  Grade C

2 (2.6%)

2 (4.8%)

0 (0%)

Readmission

9 (11.7%)

8 (19%)

1 (2.9%)

0.09

30-Day mortality

10 (13%)

7 (16.7%)

3 (8.6%)

0.53

  1. OBA Opioid-Based Anesthesia, OFA Opioid-Free Anesthesia, CCI Comprehensive Complication Index, POPF Post-Operative Pancreatic Fistula, DGE Delayed Gastric Emptying. (ns: P > 0.05; *: P < 0.05; **: P < 0.01; ***: P < 0.001; ****: P < 0.0001)