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Table 3 Mean arterial pressure, vasopressor use, and clinical outcomes

From: The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care

Variable Usual care before vs. during the trial Usual care pre-trial vs. non-enrolled vs. usual care controls
Pre-trial period
(N = 200)
During-trial period
(N = 229)
p-value Pre-trial group
(N = 200)
Non-enrolled group (N = 155) Usual Care control group
(N = 74)
p-value
Mean Arterial Pressure (MAP)
MAP while receiving vasopressors (mean [SD]) 72.5 (5.1) 72.4 (5) 0.76 72.5 (5.1) 72.3 (5.1) 72.5 (4.9) 0.92
MAP prescribed (mean [SD]) 64.7 (3.1) 65.3 (3.7) 0.08 64.7 (3.1) 65.1 (3.3) 65.5 (4.5) 0.15
Vasopressor use
Vasopressor duration, hours (mean [SD]) 48.5 (44.3) 43.6 (40.5) 0.24 48.5 (44.3) 45.3 (41.1) 40.3 (39.2) 0.36
Vasopressor dose-rate, μg/kg/min (mean [SD]) 0.21 (0.3) 0.23 (0.37) 0.53 0.21 (0.3) 0.25 (0.41) 0.2 (0.27) 0.47
Vasopressor total dose, mg (mean [SD]) 60.1 (122) 56.6 (104.9) 0.75 60.1 (121.9) 62.9 (118.6) 43.4 (66.5) 0.45
Vasopressor(s) restarted, n (%) 22 (11) 36 (15.7) 0.15 22 (11) 26 (16.8) 10 (13.5) 0.29
Clinical Outcomes
ICU Stay, days (median [IQR]) 4.0 (2.2–8.4) 5.0 (2.6–9.0) 0.43 4.0 (2.2–8.4) 5.1 (2.3–8.6) 5.3 (3.0–9.8) 0.24
Hospital Stay, days (median [IQR]) 13.7 (7.3–25.4) 12.9 (7.0–25.1) 0.46 13.7 (7.3–25.4) 12.6 (6.6–24.1) 14.3 (8.5–28.1) 0.47
ICU readmission(s), n (%) 13 (6.5) 20 (8.7) 0.39 13 (6.5) 11 (7.1) 9 (12.2) 0.28
Patients with ≥1 complication, n (%) 88 (44.0) 98 (42.8) 0.80 88 (44.0) 73 (47.1) 25 (33.8) 0.16
Mortality (ICU), n (%) 52 (26.0) 66 (28.8) 0.51 52 (26.0) 46 (29.7) 20 (27.0) 0.74
Mortality (Hospital), n (%) 75 (37.5) 78 (34.1) 0.46 75 (37.5) 54 (34.8) 24 (32.4) 0.71
  1. Abbreviations: MAP mean arterial pressure, ICU intensive care unit, IQR interquartile range, SD standard deviation