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Table 1 Eligibility Criteria

From: The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care

PRE-TRIAL PERIOD DURING-TRIAL PERIOD
Pre-trial group Non-enrolled group Usual care control group
Inclusion criteria Inclusion criteria Inclusion criteria
•-At least 65 years of age
•-Admitted to ICU with hypotension as a diagnosis
•-Receiving vasopressor therapy for at least 6 consecutive hours in the ICU during index hospitalization
•-At least 65 years of age
•-Admitted to ICU with hypotension as a diagnosis
•-Receiving vasopressor therapy for at least 6 consecutive hours in the ICU during index hospitalization
•-At least 65 years of age
•-Working diagnosis of vasodilatory hypotension as assessed by treating team
•-Vasopressors started < 12 h before randomization
•-Vasopressors expected for 6 additional hours as assessed by the treating team
Exclusion criteria Exclusion criteria Exclusion criteria
•-Treated for brain or spinal injury or acute brain injury during index hospitalization
•-Vasopressors administered solely for: bleeding, acute ventricular failure or post-cardiopulmonary bypass vasoplegia
•-Organ transplant within the past year
•-Received ECMO during index hospitalization
•-Treated for brain or spinal injury or acute brain injury during index hospitalization
•-Vasopressors administered solely for: bleeding, acute ventricular failure or post-cardiopulmonary bypass vasoplegia
•-Organ transplant within the past year
•-Received ECMO during index hospitalization
•-Actively treated for brain injury or spinal cord injury
•-Vasopressors being given solely for bleeding, acute ventricular failure or post-cardiopulmonary bypass vasoplegia
•-Lacking commitment to life-sustaining therapies
•-Death perceived as imminent
•-Previously enrolled in OVATION-65
•-Organ transplant within the last year
•-ECMO at baseline
•-The treating physician(s) lacks equipoise regarding the overall effects of permissive hypotension versus usual care on patient important outcomes
  1. Abbreviations: ECMO extracorporeal membrane oxygenation, OVATION-65 Optimal VAsopressor TitratION in patients 65 years and older, ICU intensive care unit