Fig. 2

Mean arterial pressure over time. The x axis indicates the months from trial initiation. The y axis represents mean MAP. The dotted line indicates the trial initiation at each site, which was a different date at each site, and separates the pre-trial period, N = 200 (months − 13 to − 1) of the during-trial period, N = 229 (months 0–23). The number of patients included and the number of participating sites for each month are specified at the bottom of the figure