Table 5 Univariate analysis of influence on sufentanil consumption 48 hours after hepatectomy
Characteristics | Number (n, %) | Median, IQR | P |
|---|---|---|---|
Age (years old) | |||
 ≤60 | 308 (54.8%) | 98.00 (70.00, 143.50) |  |
 >60 | 254 (45.2%) | 82.00 (62.75, 120.00) | <0.001* |
Gender | |||
 Male | 316 (56.2%) | 94.50 (65.25, 139.00) |  |
 Female | 246 (43.8%) | 88.00 (63.75, 124.00) | 0.183 |
BMI (kg/m2) | |||
 ≤25 | 413 (73.5%) | 90.00 (65.50, 131.50) |  |
 >25 | 149 (26.5%) | 92.00 (64.00, 134.00) | 0.971 |
Intraoperative blood loss (ml) | |||
 ≤800 | 487 (86.7%) | 90.00 (64.00, 131.00) |  |
 >800 | 75 (13.3%) | 99.00 (73.00, 155.00) | 0.054 |
Operative time (min) | |||
 ≤300 | 422 (75.1%) | 86.50 (63.00, 130.00) |  |
 >300 | 140 (24.9%) | 103.0 (71.25, 140.00) | 0.008* |
Intraoperative transfusion | |||
 No | 364 (64.8%) | 86.50 (63.00, 125.00) |  |
 Yes | 198 (35.2%) | 100.50 (71.50, 141.25) | 0.002* |
Intraoperative transfusion of RBC (u) | |||
 ≤2 | 453 (80.6%) | 90.00 (64.00, 132.00) |  |
 >2 | 109 (19.4%) | 94.00 (72.50, 139.00) | 0.165 |
Extent of resection | |||
 Minor hepatic resection | 272 (48.4%) | 77.00 (57.00, 102.00) |  |
 Major hepatic resection | 290 (51.6%) | 114.00 (76.00, 155.00) | <0.001* |
Surgical approach | |||
 Laparoscope | 302 (53.7%) | 82.00 (58.75, 119.25) |  |
 Open | 260 (46.3%) | 106.50 (74.00, 147.75) | <0.001* |
ASA classification | |||
 I+II | 506 (90.0%) | 91.25 (64.88, 133.00) |  |
 III | 56 (10.0%) | 86.00 (63.25, 135.00) | 0.404 |
Introperative dexmedetomidine | |||
 No | 67 (11.9%) | 91.50 (65.00, 133.00) |  |
 Yes | 495 (88.1%) | 88.00 (62.00, 133.00) | 0.758 |
Postoperative NSAIDs | |||
 No | 170 (30.3%) | 92.00 (64.13, 132.00) |  |
 Yes | 392 (69.7%) | 87.50 (64.00, 133.88) | 0.848 |
PONV | |||
 No | 525 (93.4%) | 90.00 (64.00, 130.50) |  |
 Yes | 37 (6.6%) | 111.00 (76.50, 145.50) | 0.030* |
Tumor number | |||
 Solitary | 491(87.4%) | 92.00 (64.00, 133.00) |  |
 Multiple | 71 (12.6%) | 96.50(69.75, 141.25) | 0.631 |
Tumor's size (cm) | |||
 ≤5 | 408 (72.6%) | 92.00 (65.25, 133.75) |  |
 >5 | 154 (27.4%) | 86.50 (63.00, 127.00) | 0.491 |
Cut margin | |||
 Free | 532 (94.7%) | 90.00(64.25, 132.00) |  |
 Infiltrated | 30 (5.3%) | 100.00 (63.75, 138.75) | 0.499 |
Differentiation | |||
 Well or moderate | 424 (75.4%) | 90.00 (64.00, 130.00) |  |
 Poor | 138 (24.6%) | 92.00 (66.00, 140.00) | 0.964 |
Vascular invasion | |||
 No | 502 (89.3%) | 90.50 (64.00, 131.25) |  |
 Yes | 60 (10.7%) | 94.50 (65.75, 146.50) | 0.438 |
lymph nodes infiltration | |||
 No | 446(79.4%) | 74.00(56.50, 112.00) |  |
 Yes | 116(20.6%) | 97.00(64.75, 134.75) | 0.540 |
Preoperative laboratory data | |||
 AST (U/l) | |||
  ≤40 | 376 (66.9%) | 93.50 (64.00, 135.50) |  |
  >40 | 186 (33.1%) | 90.00 (65.75, 128.25) | 0.355 |
 ALT (U/l) | |||
  ≤40 | 409 (72.8%) | 94.00 (64.00, 134.50) |  |
  >40 | 153 (27.2%) | 85.00 (65.50, 125.00) | 0.135 |
 Alkaline phosphatase (U/l) | |||
  ≤94 | 211 (37.5%) | 94.00 (62.00, 134.00) |  |
  >94 | 351 (62.5%) | 90.00 (67.00,132.00) | 0.790 |
 Albumin (g/l) | |||
  ≤35 | 155 (27.6%) | 83.00 (63.00, 125.00) |  |
  >35 | 407 (72.4%) | 94.00 (65.00, 134.00) | 0.112 |
 BUN (mmol/l) | |||
  ≤7.5 | 522 (92.9%) | 90.00 (64.00, 130.00) |  |
  >7.5 | 40 (7.1%) | 111.50 (72.00, 151.75) | 0.072 |
 Creatinine (μmol/l) | |||
  ≤73 | 362 (64.4%) | 88.50 (65.00, 129.75) |  |
  >73 | 200 (35.6%) | 95.00(64.00, 139.00) | 0.218 |
Platelet count (×109/l) | |||
  ≤100 | 77 (13.7%) | 97.00 (67.00, 139.00) |  |
  >100 | 485 (86.3%) | 90.00 (64.00, 131.50) | 0.249 |
 Prothrombin time (s) | |||
  ≤14 | 444 (79.0%) | 90.50 (64.00, 130.00) |  |
  >14 | 118 (21.0%) | 93.50 (64.75, 137.00) | 0.515 |
Postoperative laboratory data | |||
 AST (U/l) | |||
  ≤40 | 121 (21.5%) | 98.00 (70.00, 143.00) |  |
  >40 | 441 (78.5%) | 89.00 (64.00, 130.00) | 0.162 |
 ALT (U/l) | |||
  ≤40 | 159 (28.3%) | 97.00 (72.00, 134.00) |  |
  >40 | 403 (71.7%) | 88.00 (63.00,132.00) | 0.119 |
 Alkaline phosphatase (U/l) | |||
  ≤94 | 252 (44.8%) | 92.50 (64.00, 134.00) |  |
  >94 | 310 (55.2%) | 90.00 (66.00, 132.00) | 0.775 |
 Albumin (g/l) | |||
  ≤35 | 389 (69.2%) | 88.00 (63.00, 131.00) |  |
  >35 | 173 (30.8%) | 97.00 (70,00, 133.50) | 0.093 |
 BUN (mmol/l) | |||
  ≤7.5 | 536 (95.4%) | 90.00 (64.00, 132.00) |  |
  >7.5 | 26 (4.6%) | 118.50 (74.75, 177.25) | 0.051 |
 Creatinine (μmol/l) | |||
  ≤73 | 362 (64.4%) | 90.00 (63.00, 133.00) |  |
  >73 | 200 (35.6%) | 95.00 (68.25, 132.75) | 0.310 |