Table 1 Analgesic activity of brimonidine assessed by acetic acid-induced writhing in mice
From: Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
Group | Dose mg/kg | Number of writhes | % Inhibition |
|---|---|---|---|
Control | 0 | 63.0 ± 7.3 | – |
High dose | 0.4 | 0*** | 100 |
Medium dose | 0.08 | 7.8 ± 4.3*** | 87.6 |
Low dose | 0.016 | 10.6 ± 4.5*** | 82.5 |