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Table 2 Results of Measurement of Cytokines Interleukin-6 and Interleukin -8

From: Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study

Subject number

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

Cancer

Esoph.

CCA

Rectal

Esoph.

CCA

Pancr.

Gist

Colon

CCA

Coecum

+Ovar.

Pancr.

Pancr.

Bile duct

Rectal

Bile duct

pCCC

Surgery blood (mL)

Dilution fluid (mL)

1,400

550

500

0

2,800

2,500

1,600

1,000

1,100

500

1,600

500

800

300

950

300

1,000

700

2,200

200+800

800

150

1,700

1,400

1,661

900

2,600

50

1,400

100

800

200

IL-6/

IL-8

(pg/mL)

Reservoir

BLQ/

6

BLQ/

92

2633/

322

90/

16

257/

518

121/

25

163/

75

23/

17

BLQ/

9

2617/

76

688/

232

43/

108

284/

100

2271/

157

76/

56

244/

114

EC

1054/

1032

25/

103

219/

1046

727/

569

221/

199

91/

25

267/

102

17/

10

-

1070/

383

49/

353

243/

97

317/

138

191/

180

264/

284

29/

821

LDF

408/

24

55/

112

236/

139

780/

13

317/

58

114/

9

260/

24

22/

BLQ

BLQ/

BLQ

2488/

72

20/

5

492/

86

184/

17

554/

11

1289/

67

BLQ/

21

IL-6/

IL-8

(total, ng)

Reservoir

14.7/

8.4

5.2/

46

7372/

901

144/

26

283/

570

194/

40

130/

60

22/

16

11/

09

5757/

167

550/

186

73/

184

472/

166

5904/

408

106/

78

195/

91

LDF

43.6/

2.6

2.3/

4.6

27/

16

49/

0.8

20/

4

17/

1

17/

2

1/

0.1

0.4/

0.1

264/

8

1/

0.2

33/

6

8/

0.7

177/

4

77/

4

2/

4

  1. BLQ: below the limit of quantification of 9.8 pg/mL for IL-6 and 3.1 pg/mL for IL-8
  2. CCA: cholangiocarcinoma; EC: erythrocyte concentrate; Esoph.: esophageal cancer; IL: interleukin; LDF: leukocyte depletion filter; Ovar.: ovarian cancer; Pancr.: pancreatic cancer; pCCC: perihilar cholangiocellular carcinoma