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Table 2 Results of Measurement of Cytokines Interleukin-6 and Interleukin -8

From: Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study

Subject number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Cancer Esoph. CCA Rectal Esoph. CCA Pancr. Gist Colon CCA Coecum
+Ovar.
Pancr. Pancr. Bile duct Rectal Bile duct pCCC
Surgery blood (mL)
Dilution fluid (mL)
1,400
550
500
0
2,800
2,500
1,600
1,000
1,100
500
1,600
500
800
300
950
300
1,000
700
2,200
200+800
800
150
1,700
1,400
1,661
900
2,600
50
1,400
100
800
200
IL-6/
IL-8
(pg/mL)
Reservoir BLQ/
6
BLQ/
92
2633/
322
90/
16
257/
518
121/
25
163/
75
23/
17
BLQ/
9
2617/
76
688/
232
43/
108
284/
100
2271/
157
76/
56
244/
114
EC 1054/
1032
25/
103
219/
1046
727/
569
221/
199
91/
25
267/
102
17/
10
- 1070/
383
49/
353
243/
97
317/
138
191/
180
264/
284
29/
821
LDF 408/
24
55/
112
236/
139
780/
13
317/
58
114/
9
260/
24
22/
BLQ
BLQ/
BLQ
2488/
72
20/
5
492/
86
184/
17
554/
11
1289/
67
BLQ/
21
IL-6/
IL-8
(total, ng)
Reservoir 14.7/
8.4
5.2/
46
7372/
901
144/
26
283/
570
194/
40
130/
60
22/
16
11/
09
5757/
167
550/
186
73/
184
472/
166
5904/
408
106/
78
195/
91
LDF 43.6/
2.6
2.3/
4.6
27/
16
49/
0.8
20/
4
17/
1
17/
2
1/
0.1
0.4/
0.1
264/
8
1/
0.2
33/
6
8/
0.7
177/
4
77/
4
2/
4
  1. BLQ: below the limit of quantification of 9.8 pg/mL for IL-6 and 3.1 pg/mL for IL-8
  2. CCA: cholangiocarcinoma; EC: erythrocyte concentrate; Esoph.: esophageal cancer; IL: interleukin; LDF: leukocyte depletion filter; Ovar.: ovarian cancer; Pancr.: pancreatic cancer; pCCC: perihilar cholangiocellular carcinoma