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Table 1 Results of Measurement of EpCAM-Positive Tumor Cells

From: Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study

Subject number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Cancer Esoph. CCA Rectal Esoph. CCA Pancr. Gist Colon CCA Coecum
+Ovar.
Pancr. Pancr. Bile duct Rectal Bile duct pCCC
Surgery blood (mL)
Dilution fluid (mL)
1400
550
500
0
2800
2500
1600
1000
1100
500
1600
500
800
300
950
300
1000
700
2200
200 + 800
800
150
1700
1400
1661
900
2600
50
1400
100
800
200
Total number of tumor cells in IBS Reservoira 7600 0 263,076 0 14,322 108,984 108 0 0 101,525 15,529 0 0 0 0 0
Total number of tumor cells in ECb 0 192 6835 0 2756 0 0 0 0 4163 1886 69 0 0 419 0
Total number of tumor cells in EC after filtration (LDF)c 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
  1. The numbers of tumor cell in the reservoir and ECs were assessed in test samples (20 ml) and calculated to the total volume. In the EC following filtration, the total volume was consumed for tumor cell assessment
  2. CCA: cholangiocarcinoma; EC: erythrocyte concentrate; EpCAM: epithelial cell adhesion molecule; Esoph.: esophageal cancer; LDF: leukocyte depletion filter; Ovar.: ovarian cancer; Pancr.: pancreatic cancer; pCCC: perihilar cholangiocellular carcinoma
  3. a IBS Reservoir: Blood and purge solvent accumulated during surgery was collected in a reservoir containing a bone splinter filter (IBS/ Reservoir sample)
  4. b EC: Blood and purge solvent mix collected in the reservoir was centrifuged and washed using a IBS machine, resulting in an EC (EC sample)
  5. c LDF: EC was filtered using a 40 μM LDF (Haemonetics), resulting in an EC containing almost no white blood cells (LDF sample)