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Table 3 Parameter estimates of the population pharmacodynamics model for Ce of propofol and UMSS score (n = 30)

From: The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study

Parameter

Estimate, (RSE, %), [95% CI]

(μg/mL)

Median (2.5–97.5%) of bootstrap replicates (μg/mL)

Ce50UMSS ≥ 1

1.84 (8.3) [1.54–2.14]

1.85 (1.67–2.04)

Ce50UMSS ≥ 2

2.64 (8.6) [2.20–3.08]

2.66 (2.40–2.97)

Ce50UMSS ≥ 3

3.98 (4.1) [3.66–4.30]

4.00 (3.79–4.19)

Ce50UMSS ≥ 4

4.78 (2.7) [4.53–5.03]

4.81 (4.64–4.96)

γ

5.76 (15.6) [4.00–7.52]

5.78 (4.89–7.32)

  1. Parameter estimates were obtained via the Laplace method using NONMEM® 7.4.4 (ICON Development Solutions, Dublin, Ireland). Inter-individual random variability was not assumed. Bootstrap analysis was repeated 1000 times. Ce Effect-site concentration, UMSS University of Michigan Sedation Scale, Ce50UMSS ≥ n Effect-site concentration of propofol with 50% probability of UMSS score equal to or greater than n, RSE Relative standard error
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BMC Anesthesiology

ISSN: 1471-2253

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