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Fig. 6 | BMC Anesthesiology

Fig. 6

From: Sevoflurane blocks glioma malignant development by upregulating circRELN through circRELN-mediated miR-1290/RORA axis

Fig. 6

MiR-1290 aggravated Sev-inhibited cellular malignant behaviors by depleting RORA. Experimental cells in this section included control, Sev, Sev + miR-1290, Sev + miR-NC, Sev + miR-1290 + pcDNA-RORA or Sev + miR-1290 + pcDNA. A The expression of miR-1290 in Sev-treated T98G and LN18 cells transfected with miR-1290 or miR-NC was detected by qPCR. B The expression of RORA in these experimental cells was detected by western blot. C and D Cell proliferation was assessed by CCK-8 assay and colony formation assay. E Cell apoptosis was monitored by flow cytometry assay. F and G Cell cycle progression monitored by flow cytometry assay. H and I Cell migration was assessed by wound healing assay. J and K Cell migration and cell invasion were assessed by transwell assay. L and M The protein levels of MMP2 and MMP9 were measured by western blot. *P < 0.05

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BMC Anesthesiology

ISSN: 1471-2253

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