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Fig. 4 | BMC Anesthesiology

Fig. 4

From: Sevoflurane blocks glioma malignant development by upregulating circRELN through circRELN-mediated miR-1290/RORA axis

Fig. 4

CircRELN knockdown recovered cellular malignant behaviors by enriching miR-1290 in Sev-treated T98G and LN18 cells. Experimental cells in this section included Control, Sev, Sev + si-NC, Sev + si-circRELN, Sev + si-circRELN + anti-miR-NC or Sev + si-circRELN + anti-miR-1290 treatment. A The expression of miR-1290 was measured by qPCR. B and C Cell proliferation was assessed by CCK-8 assay and colony formation assay. D Cell apoptosis was assessed by flow cytometry assay. E and F Cell cycle progression was analyzed by flow cytometry assay. G and H Cell migration was assessed by wound healing assay. (I and J Cell migration and cell invasion were assessed by transwell assay. K and L The protein levels of MMP2 and MMP9 were detected by western blot. *P < 0.05

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BMC Anesthesiology

ISSN: 1471-2253

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