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Table 3 Comparison of EC50,dc, EC90,dc and EC99,dc values of CMGCD and sugammadex

From: Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study

NMBA

SRBA

EC50,dc (μM)

EC90,dc (μM)

EC99,dc (μM)

Rocuronium

CMGCD

3.81 (2.44–5.19)

10.60 (9.63–11.57)

-

Sugammadex

0.34 (0.24–0.44)

0.55 (0.48–0.62)

0.95 (0.82–1.08)

Pipecuronium

CMGCD

5.15 (4.21–6.08)

11.02 (8.95–13.08)

-

Sugammadex

0.38 (0.23–0.54)

0.58 (0.43–0.74)

0.95 (0.69–1.20)

Vecuronium

CMGCD

101.2 (73.9–128.4)

306.0 (172.7–439.2)

-

Sugammadex

0.32 (0.23–0.41)

0.68 (0.54–0.83)

1.67 (1.08–2.26)

  1. Values are given as mean and 95% confidence interval. EC50,dc, EC90,dc and EC99,dc, effective concentrations for 50, 90, and 99% effect, respectively, of relaxant binding agents normalized to the neuromuscular blocking agent concentration. CMGCD Carboxymethyl-γ-cyclodextrin