Fig. 5

Overexpression of ROCK1 aggravates CIRI in MCAO rats by increasing the extent of NF-κB phosphorylation. A Neurological deficit scores for MCAO rats injected with oe-ROCK1. B ROCK1 expression and extent of NF-κB phosphorylation in rat hippocampal neuronal cells determined by immunohistochemical staining. C Infarction area of rats injected with oe-ROCK1 observed by TTC staining. D Damage of neurons in hippocampal regions determined by HE staining. E Apoptosis rate of neuronal cells in hippocampal regions examined by TUNEL staining. For panel A, C, and E, comparisons were made using unpaired t test. * p < 0.05 compared with rats injected with oe-NC. For panel B, comparison was made using two-way ANOVA. * p < 0.05 compared with rats injected with oe-NC