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Table 1 Clinical data and intraoperative variables of patients

From: Effects of lidocaine, dexmedetomidine, and their combination infusion on postoperative nausea and vomiting following laparoscopic hysterectomy: a randomized controlled trial

  Group C (n = 60) Group L (n = 60) Group D (n = 60) Group LD (n = 60) P-value
Age (yr) 47.2 ± 5.1 45.4 ± 3.8 46.1 ± 4.3 46.6 ± 4.4 0.629
BMI 23.0 ± 1.4 22.8 ± 1.4 22.7 ± 1.5 22.5 ± 1.3 0.747
Operation time (min) 110.9 ± 9.0 113.4 ± 9.8 109.9 ± 11.1 114.3 ± 11.7 0.079
Anesthesia time (min) 133.6 ± 11.5 134.2 ± 10.9 132.8 ± 11.1 135.4 ± 11.7 0.707
Blood loss (ml) 74.4 ± 18.5 72.3 ± 16.9 73.4 ± 16.4 71.9 ± 14.3 0.187
Intraoperative fluids (ml) 893.8 ± 155.0 855.4 ± 135.1 904.3 ± 155.9 900.0 ± 158.4 0.379
ASA I/II, n 42/18 32/28 36/24 38/22 0.300
History of PONV, n (%) 6 (10.0%) 5 (8.3%) 7 (11.7%) 5 (8.3%) 0.912
History of motion sickness, n (%) 16 (26.7%) 18 (30%) 13 (21.7%) 20 (33.3%) 0.529
Smoking, n (%) 4 (6.7%) 3 (5.0%) 2 (3.3%) 3 (5.0%) 0.873
Intraoperative awareness, n (%) 0 (0%) 0 (0%) 0 (0%) 0 (0%)  
Apfel score for PONV risk, n (%)
 1 0 (0%) 0 (0%) 0 (0%) 0 (0%)  
 2 3 (5.0%) 2 (3.3%) 1 (1.7%) 3 (5.0%) 0.736
 3 36 (60.0%) 39 (65.0%) 34 (56.7%) 41 (68.3%) 0.560
 4 21 (35.0%) 19 (31.7%) 25 (41.7%) 16 (26.7%) 0.364
Use of propofol (mg·kg−1·h−1) 5.5 ± 0.4 5.4 ± 0.3 4.9 ± 0.3*✩ 4.4 ± 0.2*✩#  < 0.001
Use of remifentanil (μg·kg−1·h−1) 9.8 ± 0.6 9.4 ± 0.5* 5.7 ± 0.8*✩ 5.3 ± 0.6*✩#  < 0.001
  1. Data are present as mean ± standard deviation or number (%)
  2. Group C Control group, Group L Lidocaine group, Group D Dexmedetomidine group, Group LD Lidocaine combined with dexmedetomidine group, BMI Body mass index, ASA American society of anesthesiologists, PONV Postoperative nausea and vomiting
  3. *P versus Group C, P versus Group L, #P versus Group D