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Table 2 Pharmacokinetic Parameters of Bupivacaine

From: Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: a phase 1 study

Parameter AUC0 − last, h*ng/mL AUC0−∞, h*ng/mL t1/2, h CL/F, mL/h Cmax, ng/mL Tmax, h
Mean (SD) 12,891.5 (3589.9) 13,171.3 (3675.4) 28.4 (10.4) 21,784.9 (6248.7) 189.9 (92.5) 39.9 (21.4)
Geometric mean 12,420.4 12,686.0 26.7 20,968.0 170.9 35.7
CV, % 27.9 27.9 36.7 28.7 48.7 53.7
Median (min-max) 12,260.2 (7505.3–19,332.1) 12,556.4 (7649.1–19,418.2) 26.7 (15.3–50.4) 21,189.3 (13,698.5–34,775.1) 150.0 (70.2–374.0) 35.0 (23.5-104.1)
  1. AUC area under the plasma-concentration-time curve; AUC0−last AUC from time 0 to last collection time after study drug administration; AUC0−∞ AUC from time 0 to infinity; CL/F clearance rate; Cmax maximum concentration; CV coefficient of variation; max maximum; min minimum, SD standard deviation; t1/2 half-life; Tmax time to reach maximum plasma concentration
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BMC Anesthesiology

ISSN: 1471-2253

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