Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: a phase 1 study

Table 2 Pharmacokinetic Parameters of Bupivacaine

Parameter	AUC_{0 − last}, h*ng/mL	AUC_0−∞, h*ng/mL	t_1/2, h	CL/F, mL/h	C_max, ng/mL	T_max, h
Mean (SD)	12,891.5 (3589.9)	13,171.3 (3675.4)	28.4 (10.4)	21,784.9 (6248.7)	189.9 (92.5)	39.9 (21.4)
Geometric mean	12,420.4	12,686.0	26.7	20,968.0	170.9	35.7
CV, %	27.9	27.9	36.7	28.7	48.7	53.7
Median (min-max)	12,260.2 (7505.3–19,332.1)	12,556.4 (7649.1–19,418.2)	26.7 (15.3–50.4)	21,189.3 (13,698.5–34,775.1)	150.0 (70.2–374.0)	35.0 (23.5-104.1)

AUC area under the plasma-concentration-time curve; AUC_0−last AUC from time 0 to last collection time after study drug administration; AUC_0−∞ AUC from time 0 to infinity; CL/F clearance rate; C_max maximum concentration; CV coefficient of variation; max maximum; min minimum, SD standard deviation; t_1/2 half-life; T_max time to reach maximum plasma concentration

ISSN: 1471-2253