Hemodynamic, renal and hormonal effects of lung protective ventilation during robot-assisted radical prostatectomy, analysis of secondary outcomes from a randomized controlled trial

Table 6 Creatinine adjusted urine samples, stratified according to HTV-l.PEEP versus LTV-h.PEEP

	Urine 1 (Baseline)	Urine 2 (Surgery)	Urine 3 (Day 1)	Urine 4 (Day 2)	P-value¹	P-value¹
U-AQP2_Cr (ng/mmol crea)	155.3 [129.8;186.6]	153.8 [119.8;186.9]	185.7 [164.5;203.1]	149.2 [120.7;182.2]	0.021
HTV-l.PEEP	165.9 [132.4;259.1]	171.2 [127.1;197.7]	192.7 [151.5;222.0]	149.2 [115.6;167.5]*	0.069	0.090
LTV-h.PEEP	143.7 [119.8;175.0]	139.0 [109.3;180.3]	184.0 [174.8;188.4]*	152.0 [120.7;225.5]	0.004	0.090
P	0.198	0.291	1.000	0.551
U-ENaC_Cr (ng/mmol crea)	87.5 [63.9;138.0]	160.0 [102.3;244.0]*	106.2 [80.2;129.7]*	121.2 [104.8;150.2]*	< 0.0001
HTV-l.PEEP	79.8 [57.0;123.5]	160.0 [110.9;259.3]*	96.1 [73.7;111.9]	108.3 [101.6;132.1]	0.005	0.627
LTV-h.PEEP	88.8 [80.4;143.0]	168.4 [102.3;240.6]*	113.9 [98.7;155.1]*	130.5 [117.0;167.9]*	0.002	0.627
P	0.198	0.843	0.089	0.045
U-NGAL_Cr (μg/mmol crea)	1.0 [0.8;2.2]	8.9 [5.1;21.9]*	1.0 [0.7;2.0]*	1.2 [0.8;2.0]	< 0.0001
HTV-l.PEEP	1.0 [0.8;2.2]	10.6 [6.8;21.9]*	1.4 [0.7;9.9]	1.1 [0.8;1.5]	0.0004	0.798
LTV-h.PEEP	1.0 [0.7;2.7]	8.3 [3.8;20.9]*	1.0 [0.6;1,5]*	1.5 [1.0;2.4]	0.0002	0.798
P	0.810	0.590	0.178	0.347

HTV-l.PEEP High tidal volume, low positive end-expiratory pressure, LTV-h.PEEP Low tidal volume, low positive end-expiratory pressure, U-AQP2_cr creatinine adjusted urinary aquaporin2, U-ENaC_Cr creatinine adjusted urinary epithelial sodium channel, U-NGAL_Cr creatinine adjusted urinary neutrophil gelatinase-associated lipocalin
All data considered non-normally distributes; shown as medians [25–75% quartiles]; Wilcoxon signed rank test used to test difference from baseline, * = p < 0.05; Mann-Whitney U test used to test difference between groups
¹P-value showing the difference in medians within groups analyzed by Friedmann test
²P-value showing the difference in medians between groups analyzed by generalized linear model

ISSN: 1471-2253