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Table 5 Urine samples, stratified according to HTV-l.PEEP versus LTV-h.PEEP

From: Hemodynamic, renal and hormonal effects of lung protective ventilation during robot-assisted radical prostatectomy, analysis of secondary outcomes from a randomized controlled trial

 

Urine 1 (Baseline)

Urine 2 (Surgery)

Urine 3 (Day 1)

Urine 4 (Day 2)

P-value1

P-value2

FeNa (%)

0.83 ± 0.30

0.83 ± 0.63

0.88 ± 0.34

0.58 ± 0.34*

0.038

 

HTV-l.PEEP

0.84 ± 0.27

0.88 ± 0.55

0.89 ± 0.37

0.60 ± 0.36*

0.237

0.939

LTV-h.PEEP

0.81 ± 0.33

0.78 ± 0.71

0.87 ± 0.32

0.56 ± 0.32*

0.255

P

0.807

0.705

0.909

0.787

  

FeK (%)

11.0 ± 3.2

12.3 ± 5.6

13.4 ± 4.0*

8.8 ± 3.6*

0.0004

 

HTV-l.PEEP

11.1 ± 3.3

12.6 ± 5.8

12.8 ± 4.2

8.2 ± 3.1*

0.011

0.475

LTV-h.PEEP

10.9 ± 3.2

12.0 ± 5.7

14.0 ± 3.8*

9.4 ± 4.2

0.047

P

0.883

0.793

0.482

0.444

  

Creatinine clearance (ml/min)3

112.0 [83.4;126.7]

45.1 [25.4;84.3]*

112.0 [92.0; 134.2]

122.0 [106.4;134.0]*

< 0.0001

 

HTV-l.PEEP

113.7 [81.3;131.2]

49.0 [32.0;75.1]*

117.8 [93.2;145.1]

123.2 [117.5;136.9]*

0.0004

0.572

LTV-h.PEEP

112.0 [83.4;117.7]

33.3 [25.4;147.3]

103.5 [92.4;131.9]

121.4 [104.9;133.7]*

0.034

P

0.722

0.833

0.514

0.525

  

UACR (mmol/mmol crea)

0.7 [0.5;1.4]

11.3 [8.0;24.3]*

15.8 [12.9;19.6]*

12.8 [10.1;18.7]*

< 0.0001

 

HTV-l.PEEP

0.8 [0.5;1.3]

13.0 [6.8;22.7]*

13.1 [7.3;18.5]*

10.7 [7.7;13.3]*

0.0002

0.312

LTV-h.PEEP

0.7 [0.4;1.1]

11.2 [9.6;28.6]*

17.4 [15.0;20.3]*

16.4 [12.8;24.6]*

< 0.0001

P

0.630

0.671

0.089

0.012

  
  1. HTV-l.PEEP High tidal volume, low positive end-expiratory pressure, LTV-h.PEEP Low tidal volume, low positive end-expiratory pressure, FeNa Fractional excretion of sodium, FeK Fractional excretion of potassium, UAER Urine albumin excretion rate, UACR Urine albumin creatinine ratio
  2. Data considered normally distributed; shown as means ± SD; paired t test used to test difference from baseline, * = p < 0.05; unpaired t test used to test difference between groups
  3. Data considered non-normally distributes; shown as medians [25–75% quartiles]; Wilcoxon signed rank test used to test difference from baseline, * = p < 0.05; Mann-Whitney U test used to test difference between groups
  4. 1P-value showing the difference in means or medians within groups analyzed by repeated measure ANOVA test or Friedmann test, respectively
  5. 2P-value showing the difference in means or medians between groups analyzed by general linear model or generalized linear model, respectively
  6. 3Calculated using the CKD-EPIcrea formula
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BMC Anesthesiology

ISSN: 1471-2253

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