Hemodynamic, renal and hormonal effects of lung protective ventilation during robot-assisted radical prostatectomy, analysis of secondary outcomes from a randomized controlled trial

Table 4 Blood samples, stratified according to HTV-l.PEEP versus LTV-h.PEEP

	Blood 1 (Baseline)	Blood 2 (Surgery, 1 h)	Blood 3 (Surgery, end)	Blood 4 (Day 1)	Blood 5 (Day 2)	Blood 6 (Day 7)	P-value¹	P-value²
P-sodium (mmol/l)	140 ± 3	139 ± 3*	139 ± 3*	138 ± 3*	139 ± 3*	137 ± 8	0.113
HTV-l.PEEP	140 ± 1	139 ± 1*	139 ± 1*	139 ± 2*	140 ± 1	140 ± 2	0.022	0.062
LTV-h.PEEP	139 ± 4	139 ± 4	139 ± 4	137 ± 4*	138 ± 3*	135 ± 10	0.154	0.062
P	0.310	0.557	0.518	0.239	0.053	0.124
P-potassium (mmol/l)	4.0 ± 0.3	4.2 ± 0.4*	4.3 ± 0.4*	3.9 ± 0.2	4.0 ± 0.3	4.0 ± 0.2	< 0.0001
HTV-l.PEEP	4.1 ± 0.3	4.4 ± 0.3*	4.5 ± 0.3*	4.1 ± 0.2	4.2 ± 0.2	4.1 ± 0.3	< 0.0001	0.889
LTV-h.PEEP	3.9 ± 0.3	4.1 ± 0.5	4.2 ± 0.4*	3.8 ± 0.2	3.9 ± 0.2	4.0 ± 0.2	0.0004	0.889
P	0.125	0.126	0.042	0.0009	0.002	0.134
P-albumin (g/l)	40 ± 2	36 ± 2*	34 ± 2*	35 ± 2*	36 ± 2*	38 ± 3*	< 0.0001
HTV-l.PEEP	40 ± 2	35 ± 2*	34 ± 2*	35 ± 1*	37 ± 2*	38 ± 3	< 0.0001	0.131
LTV-h.PEEP	40 ± 2	36 ± 2*	35 ± 2*	35 ± 2*	36 ± 3*	37 ± 3*	< 0.0001	0.131
P	0.543	0.189	0.392	0.602	0.207	0.470
P-creatinine (μmol/l)	84 ± 10	83 ± 12	90 ± 12*	83 ± 12	83 ± 11	82 ± 10*	0.0001
HTV-l.PEEP	85 ± 9	83 ± 8	91 ± 10*	83 ± 13	82 ± 8	82 ± 10	0.001	0.773
LTV-h.PEEP	83 ± 11	84 ± 16	89 ± 15	82 ± 11	85 ± 14	81 ± 11	0.054	0.773
P	0.551	0.858	0.835	0.857	0.525	0.728

HTV-l.PEEP High tidal volume, low positive end-expiratory pressure, LTV-h.PEEP Low tidal volume, low positive end-expiratory pressure
All data are considered normally distributed; shown as means ± SD; paired t test used to test difference from baseline, * = p < 0.05; unpaired t test used to test difference between groups
¹P-value showing the difference in means within groups analyzed by repeated measure ANOVA test
²P-value showing the difference in means between groups analyzed by general linear model

ISSN: 1471-2253