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Table 2 Comparison of the pEC50 of four vasoactive drugs in different blood vessels

From: Effects of different vasopressors on the contraction of the superior mesenteric artery and uterine artery in rats during late pregnancy

 

Phenylephrine

(P)

Norepinephrine

(N)

Metaraminol

(M)

Vasopressin

(V)

pEC50

Uterine artery

5.223 ± 0.083

4.493 ± 1.35

5.084 ± 0.17

7.87 ± 0.56

Mesenteric artery

5.252 ± 0.06

5.617 ± 0.11

4.92 ± 0.10

7.958 ± 0.38

P value(pEC50)

 Uterine artery vs. Mesenteric artery

0.325

0.009#

0.007#

0.649

  1. pEC50 = negative logarithm of the concentration of vasopressor agent required to elicit 50% maximum response. #P < 0.05 for uterine artery vs. mesenteric artery. The results showed that norepinephrine induced a stronger contraction in the mesenteric artery than the uterine artery (5.617 ± 0.11 vs. 4.493 ± 1.35, p = 0.009), and metaraminol induced stronger contractions in the uterine artery than the mesenteric artery (5.084 ± 0.17 vs. 4.92 ± 0.10, p = 0.007)
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BMC Anesthesiology

ISSN: 1471-2253

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